Home LiteratureArticle Details
PMID: 5358587 Published · ppublish English Journal Article

Spontaneous achlorhydria with atrophic gastritis in the Zollinger-Ellison syndrome.

Gut ·Vol. 10 ·No. 11 ·1969-11-00 ·Pages 935-9

Desai HG, Antia FP

Abstract

This case report describes the occurrence of spontaneous, persistent achlorhydria in a patient with markedly raised basal acid secretion and diarrhoea for over two years (Zollinger-Ellison syndrome). Achlorhydria was due to the rapid development of severe atrophic gastritis in a gastric mucosa that had previously shown markedly increased numbers of parietal cells.

MeSH Terms
Achlorhydria/complications Atropine/pharmacology Gastric Mucosa/pathology Gastritis/complications Humans Male Middle Aged Radiography Stomach/diagnostic imaging,drug effects,physiopathology Zollinger-Ellison Syndrome/complications,diagnostic imaging,physiopathology
Chemicals
Atropine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Desai H G
Antia F P
References (25)
25 references, click to expand
  1. THE ZOLLINGER-ELLISON SYNDROME: RE-APPRAISAL AND EVALUATION OF 260 REGISTERED CASES.
    Ann Surg. 1964 Sep;160:512-30 PMID: 14206854
  2. ULCEROGENIC TUMOR OF THE PANCREAS.
    JAMA. 1964 Oct 19;190:181-4 PMID: 14246586
  3. PANCREATIC ADENOMA WITH INTRACTABLE DIARRHEA, HYPOKALEMIA, AND HYPERCALCEMIA.
    JAMA. 1964 Oct 5;190:30-4 PMID: 14198901
  4. Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet-cell hyperplasia.
    Lancet. 1959 Jan 17;1(7064):120-3 PMID: 13621654
  5. Pancreatic islet tumor with severe diarrhea.
    Am J Med. 1960 Sep;29:529-33 PMID: 13692695
  6. WATERY DIARRHOEA AND AN ISLET CELL TUMOUR.
    Gut. 1964 Aug;5:359-62 PMID: 14209921
  7. Ulcerogenic tumors of the pancreas.
    Am J Surg. 1958 Mar;95(3):359-65 PMID: 13508965
  8. Zollinger-Ellison syndrome treated with poldine methyl methosulphate.
    Lancet. 1962 May 12;1(7237):1002-4 PMID: 14463015
  9. Gastric secretion in ulcerogenic tumors of the pancreas.
    Ann Intern Med. 1967 Oct;67(4):808-15 PMID: 6052855
  10. Steatorrhea associated with ulcerogenic tumor of the pancreas.
    Am J Med. 1958 Sep;25(3):456-9 PMID: 13571260
  11. Islet tumours of the pancreas with intractable diarrhoea.
    Gut. 1961 Mar;2:12-7 PMID: 13775800
  12. EXCLUDED GASTRIC ANTRUM SIMULATING THE ZOLLINGER-ELLISON SYNDROME.
    Gastroenterology. 1964 Aug;47:184-7 PMID: 14201408
  13. SPONTANEOUS REMISSION OF ZOLLINGER-ELLISON SYNDROME.
    Arch Intern Med. 1965 Jan;115:42-7 PMID: 14219500
  14. Mechanism of the disordered physiology involved in the Zollinger-Ellison syndrome. Report of a case.
    Am J Dig Dis. 1962 May;7:401-19 PMID: 13911482
  15. Ulcerogenic tumors of the duodenum.
    Ann Surg. 1961 Feb;153:214-27 PMID: 13730155
  16. Effects of extracts of primary and metastatic pancreatic islet cell tumors on gastric secretion.
    Gastroenterology. 1963 May;44:631-6 PMID: 13952167
  17. Nature of the gastric secretagogue in Zollinger-Ellison tumours.
    Lancet. 1967 Sep 9;2(7515):543-4 PMID: 4166897
  18. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas.
    Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8 PMID: 13259432
  19. Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia.
    Am J Med. 1958 Sep;25(3):374-80 PMID: 13571250
  20. Zollinger-Ellison syndrome in a Bantu woman, with isolation of a gastrin-like substance from the primary and secondary tumors. I. Case report.
    Gastroenterology. 1961 Aug;41:77-86 PMID: 13766943
  21. Effect of total gastrectomy on the Zollinger-Ellison tumor: observations by second-look procedures.
    Surgery. 1967 Oct;62(4):609-13 PMID: 4293695
  22. Extraction of a gastrin-like substance from a pancreatic tumour in a case of Zollinger-Ellison syndrome.
    Lancet. 1960 May 14;1(7133):1045-8 PMID: 13851712
  23. Pancreatic tumor associated with flushing and diarrhea. Report of a case.
    N Engl J Med. 1961 Mar 2;264:436-9 PMID: 13727026
  24. Gastric secretion with ulcerogenic islet cell tumor. Importance of basal acid output.
    Arch Intern Med. 1966 May;117(5):667-72 PMID: 5935020
  25. Antibodies to the carboxyl-terminal tetrapeptide of gastrin.
    Gastroenterology. 1967 Nov;53(5):697-705 PMID: 4168688
Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
Published
1969-11-00
Pages
935-9
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1553056
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]