Dentin matrix transformation: rapid induction of alkaline phosphatase and cartilage.

Science (New York, N.Y.) ·Vol. 167 ·No. 3919 ·1970-02-06 ·Pages 896-8

Huggins CB, Urist MR

Abstract

An acid-insoluble fraction of rat dentin rapidly initiates a chain reaction in mesenchyma after allogeneic transplantation to the subcutaneous tissues. The tooth matrix induced alkaline phosphatase activity within 24 hours; cartilage appeared within 5 days; bone and bone marrow formed within 14 days. The induced cartilage disappeared within 5 weeks, but bone persisted at least 1 year.

MeSH Terms

Alkaline Phosphatase/metabolism Animals Cartilage/cytology Cell Transformation, Neoplastic Dentin/transplantation Dentin Solubility Enzyme Induction Osteogenesis Rats Transplantation, Homologous

Chemicals

Alkaline Phosphatase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Huggins C B

Urist M R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.167.3919.896

Published

1970-02-06

Pages

896-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.167.3919.896 View journal details

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