Lymphocyte transformation in multiple sclerosis.

British medical journal ·Vol. 2 ·No. 5701 ·1970-04-11 ·Pages 91-2

Bartfeld H, Atoynatan T

Abstract

Lymphocytes in cultures of peripheral blood cells from patients with multiple sclerosis showed significant blastogenic transformation in the presence of human brain extract, encephalitogenic myelin basic protein, or human cerebrospinal fluid, but not in the presence of kidney extract. There was no correlation between the degree of activity of the patients' disease and the percentage transformation of their lymphocytes.

MeSH Terms

Amyotrophic Lateral Sclerosis/immunology Antigens Brain/immunology Cerebrospinal Fluid/immunology Humans Kidney/immunology Lymphocyte Activation Lymphocytes/immunology Multiple Sclerosis/immunology Myelin Sheath/immunology Nerve Tissue Proteins Tissue Extracts/pharmacology

Chemicals

Antigens Nerve Tissue Proteins Tissue Extracts

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bartfeld H

Atoynatan T

References (6)

6 references, click to expand

Lymphocyte transformation in mutliple sclerosis induced by cerebrospinal fluid.
N Engl J Med. 1966 Nov 10;275(19):1041-4 PMID: 5923338
Unsuccessful attempt to induce transformation by cerebrospinal fluid in cultured lymphocytes from patients with multiple sclerosis.
N Engl J Med. 1968 Jul 25;279(4):202-4 PMID: 5658683
Delayed hypersensitivity to encephalitogenic protein in disseminated encephalomyelitis.
Lancet. 1968 Nov 9;2(7576):1009-12 PMID: 4176341
Lymphocyte trnsformation induced by encephalitogenic factor in multiple sclerosis and other neurological diseases.
Lancet. 1968 Dec 7;2(7580):1205-7 PMID: 4177201
The relationship between lymphocyte transformation and immune responses. II. Correlations between transformation and humoral and cellular immune responses.
Clin Exp Immunol. 1969 Jul;5(1):155-61 PMID: 4244245
"IMMUNOLOGICAL ORGANISATION" AND ACTIVITY OF HUMAN PERIPHERAL WHITE-BLOOD-CELL CULTURES.
Lancet. 1964 Oct 10;2(7363):767-9 PMID: 14187460

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5701.91

Published

1970-04-11

Pages

91-2

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1699901

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5701.91 PMC Full Text

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