Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians.

Science (New York, N.Y.) ·Vol. 169 ·No. 3941 ·1970-07-10 ·Pages 194-6

Abramson RK, Rucknagel DL, Shreffler DC, Saave JJ

Abstract

A high frequency of Hb J Tongariki (alpha 115 Ala --> Asp) was found in a Kilenge village in New Britain. Heterozygotes had 45 to 50 percent of the Hb J component (determined by cellulose acetate electrophoresis). Two homozygotes for Hb J had no Hb A, suggesting that in this family only one Hbalpha structural locus is present.

MeSH Terms

Amino Acids/analysis Blood Protein Electrophoresis Chymotrypsin Erythrocytes, Abnormal Genes Genetics, Population Hemoglobins, Abnormal/analysis Homozygote Humans Hydrogen-Ion Concentration Melanesia Pedigree Peptides/analysis Trypsin

Chemicals

Amino Acids Hemoglobins, Abnormal Peptides Chymotrypsin Trypsin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Abramson R K

Rucknagel D L

Shreffler D C

Saave J J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.169.3941.194

Published

1970-07-10

Pages

194-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.169.3941.194 View journal details

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Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians.

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