The effect of cardiac disease on hemoglobin-oxygen binding.

The Journal of clinical investigation ·Vol. 49 ·No. 7 ·1970-07-00 ·Pages 1349-56

Woodson RD, Torrance JD, Shappell SD, Lenfant C

Abstract

The relation between degree of cardiac functional impairment and changes in hemoglobin-oxygen affinity and 2,3-diphosphoglycerate (2,3-DPG) has been studied in 39 patients with noncyanotic heart disease. A progressive decline in hemoglobin-oxygen affinity was found with worsening cardiac function as assessed by cardiac index, arteriovenous oxygen (A-V O(2)) difference, and cardiac symptoms; this alteration in hemoglobin-oxygen binding represents a significant mechanism for adaptation to the limited oxygen supply imposed by the cardiac lesion. The highly significant correlation of mixed venous blood oxygen saturation (S[unk]V(VO2)) with 2,3-DPG and the position of the oxygen dissociation curve suggests that the level of deoxygenated hemoglobin is an important in vivo regulator of hemoglobin-oxygen affinity.

MeSH Terms

Adenosine Triphosphate/blood Adult Aged Binding Sites Cardiac Catheterization Cardiac Output Erythrocytes/metabolism Female Glycerophosphates/blood Heart/physiopathology Heart Diseases/blood,physiopathology Hemoglobins/metabolism Humans Male Middle Aged Oxygen/blood Oxygen Consumption

Chemicals

Glycerophosphates Hemoglobins Adenosine Triphosphate Oxygen

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Woodson R D

Torrance J D

Shappell S D

Lenfant C

References (14)

14 references, click to expand

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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI106351

Published

1970-07-00

Pages

1349-56

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC322607

Subset

External Links

PubMed source DOI: 10.1172/JCI106351 PMC Full Text View journal details

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The effect of cardiac disease on hemoglobin-oxygen binding.

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