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PMID: 5443199 Published · ppublish English Journal Article

Bactericidal substance from Staphylococcus aureus. Biological properties.

The Journal of experimental medicine ·Vol. 131 ·No. 5 ·1970-05-01 ·Pages 1004-15

Dajani AS, Gray ED, Wannamaker LW

Abstract

A bactericidal substance previously isolated from phage type 71 Slaphylococcus aureus has been further identified and characterized. Staphylococci belonging to phage type 71 produce the substance in higher titers than staphylococci lysed by other phages in group II in addition to phage 71. Other staphylococci do not produce the bactericidal substance. The bactericidal substance shares several of the properties of bacteriocins but differs from this group of antibiotic substances in some respects. A combination of ammonium sulfate fractionation and gel filtration on a Sephadex G-100 column resulted in considerable degree of purification of the bactericidal substance. The substance is a previously unrecognized product of S. aureus and is distinct from other extracellular products of this organism.

MeSH Terms
Bacteria/drug effects Bacteriocins/isolation & purification,pharmacology Bacteriophage Typing Chemical Precipitation Chromatography, Gel Mitomycins/pharmacology Staphylococcus/analysis Ultraviolet Rays
Chemicals
Bacteriocins Mitomycins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dajani A S
Gray E D
Wannamaker L W
References (12)
12 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.131.5.1004
Published
1970-05-01
Pages
1004-15
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138827
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.131.5.1004 PMC Full Text View journal details
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