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PMID: 5444063 Published · ppublish English Journal Article

Orotidinuria induced by allopurinol.

Science (New York, N.Y.) ·Vol. 168 ·No. 3933 ·1970-05-15 ·Pages 861-2

Fox RM, Royse-Smith D, O'Sullivan WJ

Abstract

The administration of allopurinol to patients suffering from hyperuricemia and to normal subjects results in increased excretion of the pyrimidine nucleoside orotidine. Evidence is presented for the interference by allopurinol of the de novo biosynthesis of uridine 5'-phosphate in man.

MeSH Terms
Allopurinol/pharmacology Chromatography, Thin Layer Colorimetry Depression, Chemical Erythrocytes/enzymology Humans Nucleosides/urine Transferases/antagonists & inhibitors Triazines/pharmacology Uracil Nucleotides/biosynthesis
Chemicals
Nucleosides Triazines Uracil Nucleotides Allopurinol Transferases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fox R M
Royse-Smith D
O'Sullivan W J
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.168.3933.861
Published
1970-05-15
Pages
861-2
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.168.3933.861 View journal details
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