Tumorigenesis in mouse skin: inhibition by synthetic inhibitors of proteases.

Science (New York, N.Y.) ·Vol. 169 ·No. 3951 ·1970-09-18 ·Pages 1211-3

Troll W, Klassen A, Janoff A

Abstract

Three synthetic inhibitors of proteases (tosyl lysine chloromethyl ketone, tosyl phenylalanine chloromethyl ketone, and tosyl arginine methyl ester) inhibit the tumorigenesis initiated in mouse skin by 7,12-dimethylbenz(a)anthracene and promoted by croton oil or its active principle, phorbol ester. These protease inhibitors, when applied directly to mouse skin, inhibit some of the irritant effects of the tumor promoter and are not toxic.

MeSH Terms

Animals Antineoplastic Agents/pharmacology Arginine Benz(a)Anthracenes/antagonists & inhibitors Cell Transformation, Neoplastic/drug effects Chymotrypsin/antagonists & inhibitors Croton Oil/antagonists & inhibitors Depression, Chemical Esters/pharmacology Ketones/pharmacology Lysine Mice Papain/antagonists & inhibitors Phenylalanine Skin Neoplasms/chemically induced Terpenes/antagonists & inhibitors Trypsin Inhibitors/pharmacology

Chemicals

Antineoplastic Agents Benz(a)Anthracenes Esters Ketones Terpenes Trypsin Inhibitors Phenylalanine Croton Oil Arginine Chymotrypsin Papain Lysine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Troll W

Klassen A

Janoff A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.169.3951.1211

Published

1970-09-18

Pages

1211-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.169.3951.1211 View journal details

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Tumorigenesis in mouse skin: inhibition by synthetic inhibitors of proteases.

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