Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. II. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease.

The Journal of experimental medicine ·Vol. 131 ·No. 1 ·1970-01-01 ·Pages 1-19

Oldstone MB, Dixon FJ

Abstract

Tissue injury (chronic disease) associated with persistent LCM infection is apparently caused by the host immune response to the virus. Employing parabiosis or cell transfer from hyperimmune donors to isologous virus carriers, the tissue injury of chronic disease could be initiated and/or intensified. Furthermore, the transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells. The pathogenesis of the nonglomerular tissue injury of chronic LCM disease is apparently at least in part related to the interaction of circulating anti-LCM antibody with viral antigen at the tissue site. Trapping of circulating virus-antibody complexes in the glomerular filter is apparently the major cause of the glomerulonephritis.

MeSH Terms

Animals Animals, Newborn Antibody Formation Antigen-Antibody Reactions Brain/immunology Brain Diseases/etiology Complement Fixation Tests Female Glomerulonephritis/etiology,immunology Hypersensitivity, Delayed Immune Sera Inflammation Liver/immunology Liver Diseases/etiology Lymphocytic Choriomeningitis/complications,immunology Maternal-Fetal Exchange Mice Neutralization Tests Parabiosis Pregnancy Pregnancy, Animal Spleen/immunology Time Factors

Chemicals

Immune Sera

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Oldstone M B

Dixon F J

References (28)

28 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.131.1.1

Published

1970-01-01

Pages

1-19

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138769

Subset

External Links

PubMed source DOI: 10.1084/jem.131.1.1 PMC Full Text View journal details

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Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. II. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease.

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