Two forms of repair of DNA in mammalian cells following irradiation.

Biophysical journal ·Vol. 10 ·No. 3 ·1970-03-00 ·Pages 237-45

Elkind MM, Kamper C

Abstract

When Chinese hamster cells are lysed on top of an alkaline sucrose gradient, in time a fairly discrete DNA-containing molecular species is released from an apparently more complex material. Small doses of X-radiation speed the resolution of this complex while large doses degrade the material released from it. Incubation after irradiation reverses both effects.

MeSH Terms

Animals Cell Line Centrifugation, Density Gradient Cricetinae Culture Techniques DNA/metabolism,radiation effects Hydrogen-Ion Concentration Radiation Effects Sucrose Tritium

Chemicals

Tritium Sucrose DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Elkind M M

Kamper C

References (20)

20 references, click to expand

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Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(70)86296-8

Published

1970-03-00

Pages

237-45

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1367680

Subset

External Links

PubMed source DOI: 10.1016/S0006-3495(70)86296-8 PMC Full Text View journal details

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Two forms of repair of DNA in mammalian cells following irradiation.

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