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PMID: 5483323 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Interference of iron with the absorption of tetracyclines in man.

British medical journal ·Vol. 4 ·No. 5734 ·1970-11-28 ·Pages 532-4

Neuvonen PJ, Gothoni G, Hackman R, Björksten K

Abstract

Ferrous sulphate administered together with tetracycline and three of its derivatives-oxytetracycline, methacycline, and doxycycline-was found seriously to impair the absorption of these antibiotics. Thus even small doses of iron taken simultaneously should be avoided during tetracycline treatment.

MeSH Terms
Administration, Oral Adult Anti-Bacterial Agents/blood,metabolism Humans Intestinal Absorption/drug effects Iron/metabolism,pharmacology Methacycline/blood,metabolism Oxytetracycline/blood,metabolism Tetracycline/blood,metabolism
Chemicals
Anti-Bacterial Agents Iron Tetracycline Methacycline Oxytetracycline
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Neuvonen P J
Gothoni G
Hackman R
Björksten K
References (4)
4 references, click to expand
  1. Inhibition of intestinal iron transport induced by tetracycline.
    Gastroenterology. 1967 Oct;53(4):590-9 PMID: 6047919
  2. Comparison of in vitro activity and clinical pharmacology of doxycycline with other tetracyclines.
    Antimicrob Agents Chemother (Bethesda). 1966;6:134-41 PMID: 4964450
  3. The effects of various substances on the absorption of tetracycline in rats.
    Antibiotic Med Clin Ther (New York). 1957 Oct;4(10):627-41 PMID: 13470837
  4. Avidity of the tetracyclines for the cations of metals.
    Nature. 1956 Mar 3;177(4505):433-4 PMID: 13309332
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.4.5734.532
Published
1970-11-28
Pages
532-4
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1820021
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.4.5734.532 PMC Full Text
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