Turnover of mammalian phospholipids. Rates of turnover and metabolic heterogeneity in cultured human lymphocytes and in tissues of healthy, starved and vitamin A-deficient rats.

The Biochemical journal ·Vol. 119 ·No. 3 ·1970-09-00 ·Pages 481-8

Pasternak CA, Friedrichs B

Abstract

1. Choline- and inositol-labelled phospholipids of human cultured lymphocytes turn over in a biphasic manner; phytohaemagglutinin activation stimulates turnover. 2. Choline-labelled phospholipids of rat liver and kidney, but not of blood, turn over in vivo as fast as those of duodenum, ileum or colon. Turnover in the intestinal tissues is greater in fed than in starved or vitamin A-deficient rats. In each case phosphatidylcholine turns over relatively faster than sphingomyelin or lyso-phosphatidylcholine. 3. It is concluded that phospholipid turnover of the type described is a common feature of viable cells, and that metabolically favourable conditions increase, rather than decrease, turnover.

MeSH Terms

Animals Choline Colon/metabolism

Chemicals

Choline

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Pasternak C A

Friedrichs B

References (43)

43 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1190481

Published

1970-09-00

Pages

481-8

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1179377

Subset

External Links

PubMed source DOI: 10.1042/bj1190481 PMC Full Text View journal details

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Turnover of mammalian phospholipids. Rates of turnover and metabolic heterogeneity in cultured human lymphocytes and in tissues of healthy, starved and vitamin A-deficient rats.

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