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PMID: 5511571 Published · ppublish English Journal Article

Studies on the differentiation of thymus-derived lymphocytes.

The Journal of experimental medicine ·Vol. 132 ·No. 6 ·1970-12-01 ·Pages 1216-32

Owen JJ, Raff MC

Abstract

The development pathway from embryonic thymus-stem cell to peripheral thymus-derived lymphocyte has been demonstrated using the alloantigens theta (theta) and TL as surface markers of cell differentiation. On the basis of cytotoxicity tests carried out on CBA.H or A embryo thymus cultured in diffusion chambers and on CBA.H embryo thymus grafts and peripheral lymphocytes derived from them in AKR hosts, it has been concluded that two differentiation stages take place during the maturation of thymus-derived cells, namely a first step from stem cell to thymocyte and a second step from thymocyte to peripheral lymphocyte.

MeSH Terms
Animals Antigens Cell Differentiation Cytotoxicity Tests, Immunologic Embryo, Mammalian Lymphocytes/cytology,immunology Mice Thymus Gland/cytology
Chemicals
Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Owen J J
Raff M C
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30 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.132.6.1216
Published
1970-12-01
Pages
1216-32
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180504
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.132.6.1216 PMC Full Text View journal details
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