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PMID: 5523966 Published · ppublish English Journal Article

Chronic allogeneic disease. II. Development of lymphomas.

The Journal of experimental medicine ·Vol. 132 ·No. 3 ·1970-09-01 ·Pages 417-39

Armstrong MY, Gleichmann E, Gleichmann H, Beldotti L, Andre-Schwartz J, Schwartz RS

Abstract

The incidence of lymphomas in 371 CAF(1) mice injected with BALB/c spleen cells was compared with that in 324 control CAF(1) mice. A high incidence of lymphomas was found in the treated mice, but not in the control animals. The development of the neoplasms was a function of the number of parental cells administered. Analyses of the injected mice for the presence of donor cells indicated that the majority of the injected parental cells lost antihost activity, probably within 24 hr of their administration. The tumors were of host origin, as judged by transplantation tests and antigenic analysis of tumor cells.

MeSH Terms
Animals Autoimmune Diseases Cytotoxicity Tests, Immunologic Hybridization, Genetic Lymphocytes Lymphoma/immunology Macrophages Mice Microscopy, Electron Neoplasm Transplantation Neoplasms, Experimental/immunology,pathology Organ Size Spleen/transplantation Thymus Gland/immunology Transplantation, Homologous
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Armstrong M Y
Gleichmann E
Gleichmann H
Beldotti L
Andre-Schwartz J
Schwartz R S
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.132.3.417
Published
1970-09-01
Pages
417-39
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138811
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.132.3.417 PMC Full Text View journal details
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