Independence of the sodium and potassium conductance channels. A kinetic argument.

Biophysical journal ·Vol. 11 ·No. 1 ·1971-01-00 ·Pages 110-22

Hoyt RC

Abstract

Tightly coupled models for the sodium and potassium conductance changes, in which the potassium "on" process is intimately related to the sodium "on" and "off" processes, are studied. It is shown that such coupled models are incapable of simultaneously showing the observed effects of conditioning potentials on sodium inactivation and on the translation of the potassium conductance in time. It is concluded that the primary mechanisms for the sodium and potassium channels are probably independent.

MeSH Terms

Cell Membrane Electric Conductivity Kinetics Mathematics Models, Neurological Nerve Fibers, Myelinated Potassium Sodium

Chemicals

Sodium Potassium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hoyt R C

References (11)

11 references, click to expand

The influence of external potassium on the inactivation of sodium currents in the giant axon of the squid, Loligo pealei.
J Gen Physiol. 1969 Jun;53(6):685-703 PMID: 5783008
A single or dual channel in nerve membranes.
J Gen Physiol. 1968 Sep 1;52(3):553-5 PMID: 19873631
Sodium inactivation. Experimental test of two models.
Biophys J. 1970 Jul;10(7):610-7 PMID: 5449914
THE SQUID GIANT AXON. MATHEMATICAL MODELS.
Biophys J. 1963 Sep;3:399-431 PMID: 14062458
An analysis of pore size in excitable membranes.
J Gen Physiol. 1960 May;43:105-17 PMID: 14425197
A quantitative description of membrane current and its application to conduction and excitation in nerve.
J Physiol. 1952 Aug;117(4):500-44 PMID: 12991237
Sodium inactivation in nerve fibers.
Biophys J. 1968 Oct;8(10):1074-97 PMID: 5679390
Single or dual channel mechanisms.
J Gen Physiol. 1968 Sep 1;52(3):555-6 PMID: 19873632
Slow changes of potassium permeability in the squid giant axon.
Biophys J. 1966 Sep;6(5):553-66 PMID: 5970562
Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons.
J Gen Physiol. 1969 Nov;54(5):553-75 PMID: 5346528
A single channel or a dual channel mechanism for nerve excitation.
J Gen Physiol. 1968 Sep;52(3):550-6 PMID: 5673305

Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(71)86199-4

Published

1971-01-00

Pages

110-22

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1484037

Subset

External Links

PubMed source DOI: 10.1016/S0006-3495(71)86199-4 PMC Full Text View journal details

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Independence of the sodium and potassium conductance channels. A kinetic argument.

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