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PMID: 5541540 Published · ppublish English Journal Article

Deoxycytidine triphosphate deaminase: characterization of an Escherichia coli mutant deficient in the enzyme.

Journal of bacteriology ·Vol. 105 ·No. 2 ·1971-02-00 ·Pages 666-72

O'Donovan GA, Edlin G, Fuchs JA, Neuhard J, Thomassen E

Abstract

A mutant of Escherichia coli, previously shown to contain abnormal nucleoside triphosphate pools, was found to be defective in its ability to synthesize thymidine nucleotides. The defect is not in the enzyme thymidylate synthetase but in deoxycytidine triphosphate deaminase, an enzyme that supplies deoxyuridine monophosphate, the substrate for thymidylate synthetase.

MeSH Terms
Aminohydrolases/metabolism Carbon Isotopes Chromatography, Thin Layer Culture Media DNA, Bacterial/biosynthesis
Chemicals
Carbon Isotopes Culture Media DNA, Bacterial Aminohydrolases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
O'Donovan G A
Edlin G
Fuchs J A
Neuhard J
Thomassen E
References (22)
22 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.105.2.666-672.1971
Published
1971-02-00
Pages
666-72
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC248447
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.105.2.666-672.1971 PMC Full Text View journal details
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