[Uterus relaxation by highly potent Ca plus,plus-antagonistic inhibitors of electro-mechanical coupling such as Isoptin (verapamil, iproveratril), compound D 600 and Segontin (prenylamine). Experiments on the isolated virgin rat uterus].

Uterus-Relaxation durch hochaktive Ca plus,plus-antagonistische Hemmstoffe der elektro-mechanischen Koppelung wie Isoptin (Verapamil, Iproveratril), Substanz D 600 und Segontin (Prenylamin). Versuche am isolierten Uterus virgineller Ratten.

Klinische Wochenschrift ·Vol. 49 ·No. 1 ·1971-01-00 ·Pages 32-41

Fleckenstein A, Grün G, Tritthart H, Byon K

Abstract

暂无摘要

MeSH Terms

Animals Anti-Arrhythmia Agents/pharmacology Calcium/antagonists & inhibitors Cardiac Output Cardiac Volume Electrophysiology Female Heart/drug effects Heart Rate Muscle Contraction/drug effects Muscle, Smooth/drug effects Nitriles/pharmacology Oxygen Consumption Oxytocin/pharmacology Prenylamine/pharmacology Rats Sympathomimetics/pharmacology Uterus/drug effects Vasodilator Agents/pharmacology Verapamil/pharmacology

Chemicals

Anti-Arrhythmia Agents Nitriles Sympathomimetics Vasodilator Agents Oxytocin Verapamil Prenylamine Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Fleckenstein A

Grün G

Tritthart H

Byon K

References (17)

17 references, click to expand

[Effect of beta-receptor blocking agents and related substances on the excitation, contraction and energy metabolism of myocardium fibers].
Klin Wochenschr. 1968 Apr 1;46(7):343-51 PMID: 4386795
[Neutralization of the contractile effect of depolarized catelectronics by repolarization in anelectrotonus; the anode as antagonist of acetylcholine, choline, nicotine, coniine, veratrine, potassium and rubidium salts].
Pflugers Arch Gesamte Physiol Menschen Tiere. 1951;253(3):264-82 PMID: 14833861
[Problems of labor pain inhibition by pharmacological agents].
Med Klin. 1969 Jan 24;64(4):133-9 PMID: 5783923
[(N-methyl-N-homoveratryl)-gamma-aminopropyl]-3,4-dimethoxyphenyl-acetonitrile, a substance with coronary vasodilating properties].
Arzneimittelforschung. 1962 Jun;12:549-58 PMID: 13903351
[Reversible blockade of excitation-contraction coupling in rat's uterine smooth muscle by means of organic calcium antagonists (iproveratril, D 600, prenylamine)].
Pflugers Arch. 1969;307(2):R26 PMID: 5814830
A comparison of the effects of various smooth muscle relaxants on the electrical and mechanical activity of rat uterus.
J Pharmacol Exp Ther. 1969 Jul;168(1):21-30 PMID: 4978325
MOVEMENTS OF CA IN FROG HEART VENTRICLES AT REST AND DURING CONTRACTURES.
J Physiol. 1963 Jul;167:515-50 PMID: 14178833
The antagonism between Ca and Na ions on the frog's heart.
J Physiol. 1958 Oct 31;143(3):486-505 PMID: 13588569
Calcium influx in skeletal muscle at rest, during activity, and during potassium contracture.
J Gen Physiol. 1959 Mar 20;42(4):803-15 PMID: 13631205
[On the action mechanism of new coronary dilators with simultaneous oxygen saving myocardial effects, Prenylamine and Iproveratril. 1].
Z Kreislaufforsch. 1967 Jul;56(7):716-44 PMID: 5592004
[Electromechanical uncoupling on the uterine muscle by "musculotropic" relaxants].
Naunyn Schmiedebergs Arch Pharmakol. 1969;264(3):239-40 PMID: 4242391
[THE IMPORTANCE OF ENERGY-RICH PHOSPHATE FOR CONTRACTILITY AND TONUS OF THE MYOCARDIUM].
Verh Dtsch Ges Inn Med. 1964;70:81-99 PMID: 14294314
[The effect of librium in high doses on the uterus].
Gynaecologia. 1961;152:292-9 PMID: 13867674
[Further studies on the neutralization of contraction effect of acetylcholine, choline, neurine, nicotine, coniine, veratrine, potassium chloride and rubidium chloride by means of anelectrotonus].
Pflugers Arch Gesamte Physiol Menschen Tiere. 1953;257(1):1-11 PMID: 13099959
[Correct toco- and tonolysis in obstetrics].
Med Welt. 1968 Sep 21;38:2023-32 PMID: 5712896
[On the uterus resting effect of the oxyephedrine derivatives nylidrin and isoxsuprine].
Geburtshilfe Frauenheilkd. 1967 Aug;27(8):800-13 PMID: 5591239
[A new group of competitive divalent Ca-antagonists (iproveratril, D 600, prenylamine) with potent inhibitory effects on electromechanical coupling in mammalian myocardium].
Pflugers Arch. 1969;307(2):R25 PMID: 5814829

Article Info

Journal

Klinische Wochenschrift

Abbr.

Klin Wochenschr

ISSN

0023-2173

DOI

10.1007/BF01494064

Published

1971-01-00

Pages

32-41

Language

ger

Region

Germany

NLM ID

2985205R

Subset

External Links

PubMed source DOI: 10.1007/BF01494064

Analysis Services

[Uterus relaxation by highly potent Ca plus,plus-antagonistic inhibitors of electro-mechanical coupling such as Isoptin (verapamil, iproveratril), compound D 600 and Segontin (prenylamine). Experiments on the isolated virgin rat uterus].

Contact

WeChat Official Account