Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions.

Biochemical and biophysical research communications ·Vol. 42 ·No. 6 ·1971-03-19 ·Pages 1200-6

Lu AY, Kuntzman R, West S, Conney AH

Abstract

暂无摘要

MeSH Terms

Animals Benzopyrenes/metabolism Cytochromes/metabolism Dealkylation In Vitro Techniques Male Methylcholanthrene/pharmacology Microsomes, Liver/enzymology,metabolism Mixed Function Oxygenases/metabolism Phenethylamines/metabolism Phenobarbital/pharmacology Rats

Chemicals

Benzopyrenes Cytochromes Phenethylamines Methylcholanthrene Mixed Function Oxygenases Phenobarbital

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lu A Y

Kuntzman R

West S

Conney A H

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/0006-291x(71)90033-7

Published

1971-03-19

Pages

1200-6

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1016/0006-291x(71)90033-7 View journal details

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Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions.

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