Control of pyrimidine biosynthesis in human lymphocytes. Induction of glutamine-utilizing carbamyl phosphate synthetase and operation of orotic acid pathway during blastogenesis.

Adult Anhydrides Carbamates Carbon Dioxide/metabolism Carbon Isotopes Cell Differentiation Cell Line/drug effects Chemical Precipitation Chromatography, Ion Exchange Chromatography, Paper Citrulline/metabolism Culture Techniques Dactinomycin/pharmacology Electrophoresis Enzyme Induction Glutamates Glutamine/metabolism Humans Hydrolysis Lectins/pharmacology Lymphocytes/drug effects,enzymology Orotic Acid/metabolism Paper Phosphoric Acids Phosphotransferases/biosynthesis,blood,isolation & purification Puromycin/pharmacology Pyrimidines/biosynthesis Quaternary Ammonium Compounds Sulfates Uracil/biosynthesis,metabolism Uracil Nucleotides/biosynthesis,isolation & purification

Anhydrides Carbamates Carbon Isotopes Glutamates Lectins Phosphoric Acids Pyrimidines Quaternary Ammonium Compounds Sulfates Uracil Nucleotides Glutamine Carbon Dioxide Dactinomycin Citrulline Puromycin Uracil Orotic Acid Phosphotransferases