The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat.

The Journal of physiology ·Vol. 214 ·No. 1 ·1971-04-00 ·Pages 1-13

Reed JD, Sanders DJ, Thorpe V

Abstract

1. Electrical stimulation of the vagus nerves produced a parallel increase in gastric acid secretion and gastric mucosal blood flow.2. Gastric acid secretion and mucosal blood flow, stimulated by pentapeptide infusions or by vagal stimulation, were markedly and equally reduced by electrical stimulation of splanchnic nerve fibres.3. The splanchnic stimulated reduction in acid and mucosal blood flow occurred only when the rise in blood pressure, normally associated with splanchnic stimulation, was prevented by inclusion of a pressure reservoir in the circulation.4. There was evidence that the effect of the splanchnic nerves was not mediated by release of adrenaline from the adrenal medulla.

MeSH Terms

Adrenal Medulla/metabolism Animals Blood Pressure Cats Electric Stimulation Epinephrine/metabolism Gastric Juice/metabolism Gastric Mucosa/blood supply,drug effects Peptides/pharmacology Splanchnic Nerves/physiology Statistics as Topic Vagus Nerve/physiology

Chemicals

Peptides Epinephrine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Reed J D

Sanders D J

Thorpe V

References (15)

15 references, click to expand

Effect of sympathectomy on gastric secretion in total pouch dogs.
Am J Physiol. 1951 Sep;166(3):679-85 PMID: 14885457
Gastric secretion induced by histamine and its relationship to the rate of blood flow.
J Physiol. 1953 Sep;121(3):433-44 PMID: 13097383
Blood flow and secretion in the stomach.
Gastroenterology. 1967 Feb;52(2):414-20 PMID: 6020109
The inhibiting effect of epinephrine and norepinephrine on secretion induced by histamine in separated pouches of dogs.
J Pharmacol Exp Ther. 1954 Apr;110(4):447-50 PMID: 13163836
Gastric blood flow and secretion in conscious dogs.
Am J Physiol. 1967 Apr;212(4):891-6 PMID: 6024455
Gastric secretion in relation to mucosal blood flow studied by a clearance technic.
J Clin Invest. 1966 Jan;45(1):1-13 PMID: 5901177
The vascular response of the stomach to experimental alterations in the autonomic nervous system of the dog.
Am Surg. 1952 Feb;18(2):195-200 PMID: 14903531
Effects of histamine on gastric blood flow in conscious dogs.
Gastroenterology. 1966 Oct;51(4):466-72 PMID: 5922945
ADRENERGIC INNERVATION OF THE INTESTINAL WALL STUDIED BY FLUORESCENCE MICROSCOPY.
Int J Neuropharmacol. 1964 Sep;3:379-82 PMID: 14334869
Histochemical studies of the autonomic innervation of the gut.
J Pharmacol Exp Ther. 1965 Sep;149(3):358-64 PMID: 4954685
Gastric mucosal blood flow during secretory inhibition by gastrin pentapeptide and gastrone.
Gastroenterology. 1969 Apr;56(4):659-65 PMID: 4241698
Are there any centrally controlled sympathetic inhibitory fibres to the musculature of the intesine?
Acta Physiol Scand. 1959 Dec 12;47:299-309 PMID: 13808743
Gastric blood flow and acid secretion during direct intraarterial histamine administration.
Gastroenterology. 1967 Feb;52(2):216-24 PMID: 6020386
Gastric blood flow in anaesthetized cats.
J Physiol. 1968 Feb;194(3):795-807 PMID: 5636998
Comparison of prostaglandin E1 and norepinephrine on the gastric mucosal circulation.
Proc Soc Exp Biol Med. 1970 Feb;133(2):516-9 PMID: 4391836

Article Info

Journal

The Journal of physiology

Abbr.

J Physiol

ISSN

0022-3751

DOI

10.1113/jphysiol.1971.sp009415

Published

1971-04-00

Pages

1-13

Language

English

Region

England

NLM ID

0266262

PMCID

PMC1331818

Subset

External Links

PubMed source DOI: 10.1113/jphysiol.1971.sp009415 PMC Full Text View journal details

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The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat.

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