Regulation of development of hepatic glucokinase in the neonatal rat by the diet.

The Biochemical journal ·Vol. 105 ·No. 2 ·1967-11-00 ·Pages 771-7

Walker DG, Eaton SW

Abstract

1. Feeding a high-glucose diet to weanling rats showed that high hepatic glucokinase activities could be induced at 18 days of age, i.e. 2 days after development of the enzyme begins. 2. The normal development of glucokinase activity can be retarded by weaning rats on to carbohydrate-free, high-fat and high-protein diets. 3. Precocious development of the enzyme before 16 days of age cannot be induced by oral glucose administration. 4. It is concluded that the ability to synthesize glucokinase develops very rapidly and that the nature of the diet determines the normal developmental pattern.

MeSH Terms

Animals Animals, Newborn Dietary Carbohydrates Dietary Fats Dietary Proteins Enzyme Induction Glucokinase/biosynthesis Glucose/pharmacology Hexokinase/biosynthesis Liver/enzymology Rats

Chemicals

Dietary Carbohydrates Dietary Fats Dietary Proteins Hexokinase Glucokinase Glucose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Walker D G

Eaton S W

References (31)

31 references, click to expand

STUDIES OF THE PHYSIOLOGIC ROLE OF GLUCAGON.
Diabetes. 1964 Nov-Dec;13:563-8 PMID: 14223832
Multiple hexokinases of rat tissues. Purification and comparison of soluble forms.
J Biol Chem. 1966 Aug 10;241(15):3546-60 PMID: 5919684
Ontogeny of physiological regulations in the rat.
Q Rev Biol. 1957 Jun;32(2):89-137 PMID: 13477803
Hepatic glucose phosphototransferases. Variations among species.
Diabetes. 1966 Jul;15(7):475-9 PMID: 5945210
Interrelationship of glucagon, insulin and glucose. The insulinogenic effect of glucagon.
Diabetes. 1966 Dec;15(12):855-66 PMID: 5957476
Comparison of glycolytic enzyme activities in a series of human and rodent hepatomas.
Adv Enzyme Regul. 1966;4:107-14 PMID: 4294009
INFLUENCE OF ARTIFICIAL DIET ON WEIGHT GAIN AND BODY COMPOSITION OF THE NEONATAL RAT.
J Nutr. 1964 Oct;84:100-6 PMID: 14236906
Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver.
Biochem J. 1953 Oct;55(3):400-8 PMID: 13105646
The role of glucokinase in the phosphorylation of glucose by rat liver.
Biochem J. 1964 Feb;90(2):360-8 PMID: 5834248
Interrelation of actions of glucose, insulin, and glucagon on induction of adenosine triphosphate: D-hexose phosphotransferase in rat liver.
J Biol Chem. 1966 Sep 10;241(17):4055-9 PMID: 5920810
Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties.
Proc Natl Acad Sci U S A. 1965 Oct;54(4):1218-25 PMID: 5219826
Enzymes catalysing the phosphorylation of hexoses in neonatal animals.
Biol Neonat. 1965-1966;9(1):224-39 PMID: 5872076
ADAPTIVE BEHAVIOR OF HEPATIC GLUCOKINASE IN THE ALLOXAN-DIABETIC RAT.
Arch Biochem Biophys. 1964 Feb;104:225-30 PMID: 14163886
Glucagon--an essential hormone.
Am J Med. 1966 Sep;41(3):331-41 PMID: 5330634
REGULATION OF RAT LIVER ENZYMES BY NATURAL COMPONENTS OF THE DIET.
J Biol Chem. 1964 Aug;239:2420-6 PMID: 14235517
Further properties and possibel mechanism of action of adenosine 5'-triphosphate-D-glucose 6-phosphotransferase from rat liver.
Biochem J. 1967 Nov;105(2):473-82 PMID: 5583991
Hexokinase isoenzymes in liver and adipose tissue of man and dog.
Science. 1967 Jan 13;155(3759):205-7 PMID: 6015527
INTESTINAL DISACCHARIDASE ACTIVITIES IN ADULT AND SUCKLING RATS.
Biochim Biophys Acta. 1964 Nov 22;92:305-11 PMID: 14249119
Multiple molecular forms of ATP:hexose 6-phosphotransferase from rat liver.
Biochem Biophys Res Commun. 1964 Jul 1;16(4):347-52 PMID: 5871820
Insulin release induced by glucagon in organ cultures of fetal rat pancreas.
Metabolism. 1966 Jul;15(7):577-81 PMID: 5918358
Intestinal factors in the control of insulin secretion.
J Clin Endocrinol Metab. 1965 Oct;25(10):1317-24 PMID: 5320560
The development of hepatic glucokinase in the neonatal rat.
Biochem J. 1965 Dec;97(3):845-54 PMID: 5883129
Effect of fructose on lipogenesis from lactate and acetate in diabetic liver.
J Biol Chem. 1952 Jan;194(1):435-43 PMID: 14927635
Hormonal and dietary regulation of hepatic glucokinase.
Adv Enzyme Regul. 1964;2:189-200 PMID: 5863086
CITRATE AND THE CONVERSION OF CARBOHYDRATE INTO FAT. THE ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF STARVED AND RE-FED RATS.
Biochem J. 1965 Jan;94:209-15 PMID: 14342232
Changes in lipid synthesis in rat liver during development.
Biochem J. 1967 Mar;102(3):952-8 PMID: 16742515
Selective response of liver enzymes to the administration of different diets after fasting.
Arch Biochem Biophys. 1962 Jul;98:77-85 PMID: 14479668
Artificial Feeding of Neonatal Rats.
Science. 1963 Aug 9;141(3580):517-8 PMID: 17738624
THE ACTIVITY OF ALPHA-AMYLASE IN HOMOGENATES OF THE PANCREAS OF RATS DURING EARLY POSTNATAL DEVELOPMENT.
Physiol Bohemoslov. 1964;13:288-91 PMID: 14167893
Studies of small intestine during development. II. The intracellular location of intestinal beta-galactosidase.
Biochim Biophys Acta. 1963 Mar 12;67:516-9 PMID: 14028328
INTESTINAL INVERTASE: PRECOCIOUS DEVELOPMENT OF ACTIVITY AFTER INJECTION OF HYDROCORTISONE.
Science. 1964 Jan 3;143(3601):42-4 PMID: 14075709

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1050771

Published

1967-11-00

Pages

771-7

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1198378

Subset

External Links

PubMed source DOI: 10.1042/bj1050771 PMC Full Text View journal details

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Regulation of development of hepatic glucokinase in the neonatal rat by the diet.

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