Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.

Pharmacology, biochemistry, and behavior ·Vol. 7 ·No. 4 ·1977-10-00 ·Pages 289-93

Kostowski W, Jerlicz M, Bidzinski A, Hauptmann M

Abstract

Bilateral lesions of the locus coeruleus (LC) markedly increased susceptibility to the cateleptogenic effects of neuroleptics. The apomorphine-induced stereotypy was enhanced in rats with lesioned LC whilst amphetamine stereotypy was only slightly increased. No changes in locomotor activity have been observed in LC-lesioned rats treated with apomorphine and amphetamine. This data indicates that lesions of the LC produce decreased activity of dopaminergic brain neurons as well as supersensitivity of dopaminergic receptors.

MeSH Terms

Animals Apomorphine/pharmacology Behavior/drug effects Biogenic Amines/analysis Brain Chemistry/drug effects Butyrophenones/pharmacology Dextroamphetamine/pharmacology Haloperidol/pharmacology Humans Locus Coeruleus/anatomy & histology,physiology Male Motor Activity/drug effects Rats Spiperone/pharmacology Stereotyped Behavior/drug effects Time Factors

Chemicals

Biogenic Amines Butyrophenones Spiperone Haloperidol Apomorphine Dextroamphetamine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kostowski W

Jerlicz M

Bidzinski A

Hauptmann M

Article Info

Journal

Pharmacology, biochemistry, and behavior

Abbr.

Pharmacol Biochem Behav

ISSN

0091-3057

DOI

10.1016/0091-3057(77)90222-2

Published

1977-10-00

Pages

289-93

Language

English

Region

United States

NLM ID

0367050

Subset

External Links

PubMed source DOI: 10.1016/0091-3057(77)90222-2 View journal details

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Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.

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