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PMID: 563984 Published · ppublish English Journal Article

X-chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitro.

Nature ·Vol. 271 ·No. 5643 ·1978-01-26 ·Pages 329-33

Martin GR, Epstein CJ, Travis B, Tucker G, Yatziv S, Martin DW, Clift S, Cohen S

Abstract

Evidence is presented that both X chromosomes are genetically active in clonal cultures of undifferentiated female mouse teratocarcinoma stem cells derived from a spontaneous ovarian tumour. As the cells differentiate in vitro one of the X chromosomes becomes inactivated.

MeSH Terms
Animals Cell Differentiation Clone Cells Female Karyotyping Mice Sex Chromosomes Teratoma X Chromosome
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Martin G R
Epstein C J
Travis B
Tucker G
Yatziv S
Martin D W
Clift S
Cohen S
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/271329a0
Published
1978-01-26
Pages
329-33
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/271329a0 View journal details
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