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PMID: 5645856 Published · ppublish English Journal Article

Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.

The Journal of clinical investigation ·Vol. 47 ·No. 5 ·1968-05-00 ·Pages 1109-20

Messner RP, Laxidal T, Quie PG, Williams RC

Abstract

The effect of anti-gamma-globulin factors on 7S gamma-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-gamma-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S gamma-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human gammaG globulin. The antiopsonic effect of anti-gamma-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-gamma-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.

MeSH Terms
Agglutination Tests Arthritis, Rheumatoid Coombs Test Endocarditis, Subacute Bacterial/immunology Humans Immunoglobulin G Leukocytes Opsonin Proteins Phagocytosis Rheumatoid Factor Staphylococcus/immunology
Chemicals
Immunoglobulin G Opsonin Proteins Rheumatoid Factor
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Messner R P
Laxidal T
Quie P G
Williams R C
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32 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI105800
Published
1968-05-00
Pages
1109-20
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC297263
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI105800 PMC Full Text View journal details
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