Metabolism of lactose by Staphylococcus aureus and its genetic basis.

Journal of bacteriology ·Vol. 95 ·No. 6 ·1968-06-00 ·Pages 2270-4

Morse ML, Hill KL, Egan JB, Hengstenberg W

Abstract

THE METABOLISM OF LACTOSE WAS FOUND TO BE CONTROLLED BY THREE GENES: a gene for the synthesis of a beta-galactosidase attacking only phosphorylated galactosides; a gene for a protein permitting concentration of phosphorylated galactosides which probably acts by transferring phosphates to them; and a gene regulating the first two structural genes. The three genes are closely linked and may have the same order as in Escherichia coli. Galactose-6-phosphate was found to be a better inducer of lactose utilization than is galactose or any other inducer. The inhibition of induction by isopropylthiogalactoside was found to occur at the level of the protein permitting the concentration of galactoside phosphates.

MeSH Terms

Carbon Isotopes Enzyme Induction Galactose/pharmacology Galactosidases/metabolism Genes Genetics, Microbial Glycosides/pharmacology Hexosephosphates/pharmacology Lactose/metabolism Molecular Biology Mutation Staphylococcus/metabolism

Chemicals

Carbon Isotopes Glycosides Hexosephosphates Galactosidases Lactose Galactose

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Morse M L

Hill K L

Egan J B

Hengstenberg W

References (13)

13 references, click to expand

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Proc Natl Acad Sci U S A. 1967 Jul;58(1):274-9 PMID: 4292101
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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.95.6.2270-2274.1968

Published

1968-06-00

Pages

2270-4

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC315162

Subset

External Links

PubMed source DOI: 10.1128/jb.95.6.2270-2274.1968 PMC Full Text View journal details

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Metabolism of lactose by Staphylococcus aureus and its genetic basis.

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