The effects of a thiamine antagonist, pyrithiamine, on levels of selected metabolic intermediates and on activities of thiamine-dependent enzymes in brain and liver.

Adenosine Triphosphate/metabolism Animals Brain/enzymology Brain Chemistry/drug effects Gluconates/metabolism Glucose/metabolism Glutamates/metabolism Glutarates/metabolism Glycogen/metabolism Lactates/metabolism Liver/analysis,drug effects,enzymology Mice Oxidoreductases/metabolism Phosphocreatine/metabolism Pyruvates/metabolism Thiamine/antagonists & inhibitors,metabolism Tissue Extracts Transferases/metabolism

Gluconates Glutamates Glutarates Lactates Pyruvates Tissue Extracts Phosphocreatine Adenosine Triphosphate Glycogen Oxidoreductases Transferases Glucose Thiamine