A study of the end-plate potential in sodium deficient solution.
1. The effect of anticholinesterases in lengthening the end-plate potential is much more pronounced in a low-sodium solution than in an ordinary Ringer-curare solution.2. To investigate this difference, intracellular recordings of end-plate potentials and of end-plate currents in voltage-clamped muscle fibres were used.3. It was found that the very large lengthening of the end-plate potential in a low-sodium solution was due to a combination of three factors: (i) lengthening of the underlying end-plate current, (ii) an increased membrane resistance and (iii) marked inward-going (anomalous) rectification of the muscle membrane.
23 references, click to expand
-
An analysis of the end-plate potential recorded with an intracellular electrode.J Physiol. 1951 Nov 28;115(3):320-70 PMID: 14898516
-
Inhibitory action of sodium ions on transmitter release at the motor end-plate.Nature. 1967 Sep 9;215(5106):1174-6 PMID: 4294061
-
Local activity at a depolarized nerve-muscle junction.J Physiol. 1955 May 27;128(2):396-411 PMID: 14392617
-
Statistical factors involved in neuromuscular facilitation and depression.J Physiol. 1954 Jun 28;124(3):574-85 PMID: 13175200
-
Tetrodotoxin and neuromuscular transmission.Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):8-22 PMID: 4382592
-
The effect of sudden changes in ionic concentrations on the membrane potential of single muscle fibres.J Physiol. 1960 Sep;153:370-85 PMID: 13714851
-
Some properties of conductance changes at the end-plate membrane during the action of acetylcholine.J Physiol. 1963 Jun;167:128-40 PMID: 13984696
-
The influence of potassium and chloride ions on the membrane potential of single muscle fibres.J Physiol. 1959 Oct;148:127-60 PMID: 14402240
-
The chloride conductance of frog skeletal muscle.J Physiol. 1960 Apr;151:89-102 PMID: 14405647
-
Effect of nitrate and other anions on the membrane resistance of frog skeletal muscle.J Physiol. 1959 Apr 23;146(1):117-32 PMID: 13655220
-
Junctional and extra-junctional acetylcholine receptors in skeletal muscle fibres.J Physiol. 1960 Apr;151:24-30 PMID: 14422355
-
The effect of atropine on the frog sartorius neuromuscular junction.J Physiol. 1968 Mar;195(2):493-503 PMID: 5647334
-
Potassium accumulation in muscle and associated changes.J Physiol. 1941 Aug 11;100(1):1-63 PMID: 16991506
-
The potassium and chloride conductance of frog muscle membrane.J Physiol. 1962 Aug;163(1):61-103 PMID: 16992124
-
THE EFFECT OF CALCIUM ON ACETYLCHOLINE RELEASE FROM MOTOR NERVE TERMINALS.Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:496-503 PMID: 14278410
-
Quantal components of the end-plate potential.J Physiol. 1954 Jun 28;124(3):560-73 PMID: 13175199
-
PROPAGATION OF ELECTRIC ACTIVITY IN MOTOR NERVE TERMINALS.Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:453-82 PMID: 14278408
-
Reactions of the normal mammalian muscle to acetylcholine and to eserine.J Physiol. 1936 Sep 8;87(4):394-424 PMID: 16994802
-
Effects of tetrodotoxin on the neuromuscular junction.Jpn J Physiol. 1959 Jun 25;9(2):143-52 PMID: 13672686
-
Post-tetanic restoration of neuromuscular transmission blocked by D-tubocurarine.J Physiol. 1952 Oct;118(2):216-27 PMID: 13000706
-
Active phase of frog's end-plate potential.J Neurophysiol. 1959 Jul;22(4):395-411 PMID: 13673292
-
ANTAGONISM BETWEEN NA+ AND CA2+ AT THE NEUROMUSCULAR JUNCTION.Nature. 1965 Jan 16;205:296-7 PMID: 14270723
-
Stabilization and rectification of muscle fiber membrane by tetrodotoxin.Am J Physiol. 1960 May;198:934-8 PMID: 14426011
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
