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PMID: 569146 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Inactivation of the chemoattractant folic acid by cellular slime molds and identification of the reaction product.

Journal of bacteriology ·Vol. 136 ·No. 3 ·1978-12-00 ·Pages 955-9

Pan P, Wurster B

Abstract

Enzymes inactivating the chemoattractants folic acid and pterin were detected in extracellular, intracellular, and particulate fractions obtained from Dictyostelium discoideum strains NC4 and AX-2 and Polysphondylium violaceum. The products of the inactivation reaction were analyzed by thin-layer chromatography and UV spectroscopy. Results obtained indicate that folic acid and pterin were deaminated to 2-deamino folic acid and lumazine, respectively.

MeSH Terms
Aminohydrolases/metabolism Cell Fractionation Chemotaxis Dictyostelium/enzymology Folic Acid/metabolism Myxomycetes/enzymology Pterins/metabolism
Chemicals
Pterins Folic Acid Aminohydrolases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pan P
Wurster B
References (22)
22 references, click to expand
  1. A bacterial pterin deaminase.
    J Biol Chem. 1959 Apr;234(4):955-61 PMID: 13654299
  2. A new approach to the problem of aggregation in the cellular slime molds.
    Biol Bull. 1966 Feb;130(1):28-42 PMID: 5907301
  3. A theoretical study of the effects of cyclic AMP phosphodiesterases during aggregation in Dictyostelium.
    J Cell Sci. 1976 Oct;22(1):49-58 PMID: 185228
  4. Defective cyclic adenosine-3', 5'-phosphate-phosphodiesterase regulation in morphogenetic mutants of Dictyostelium discoideum.
    J Mol Biol. 1973 Mar 15;74(4):573-85 PMID: 4354075
  5. Adenosine 3':5'-cyclic monophosphate concentrations and phosphodiesterase activities during axenic growth and differentiation of cells of the cellular slime mould Dictyostelium discoideum.
    Biochem J. 1973 May;134(1):311-9 PMID: 4353085
  6. Cyclic nucleotide phosphodiesterase in Dictyostelium discoideum: interconversion of two enzyme forms.
    Science. 1972 Mar 3;175(4025):1016-8 PMID: 4333171
  7. Phosphodiesterase in Dictyostelium discoideum and the chemotactic response to cyclic adenosine monophosphate.
    Science. 1972 Mar 3;175(4025):1014-5 PMID: 4333170
  8. Folic acid as second chemotactic substance in the cellular slime moulds.
    Nat New Biol. 1972 Jun 7;237(75):181-2 PMID: 4504203
  9. Membrane-bound cyclic AMP phosphodiesterase in chemotactically responding cells of Dictyostelium discoideum.
    Eur J Biochem. 1972 Jun 23;28(1):136-42 PMID: 4340476
  10. Cyclic AMP phosphodiesterase and its inhibitor in slime mould development.
    Nat New Biol. 1972 Jan 19;235(55):90-2 PMID: 4334254
  11. Synthesis of cyclic AMP and phosphodiesterase in various species of cellular slime molds and its bearing on chemotaxis and differentiation.
    Dev Biol. 1972 Dec;29(4):402-9 PMID: 4347961
  12. The acrasin activity of adenosine-3',5'-cyclic phosphate.
    Proc Natl Acad Sci U S A. 1967 Sep;58(3):1152-4 PMID: 4861307
  13. Cyclic 3',5'-adenosine monophosphate phosphodiesterase produced by the slime mold Dictyostelium discoideum.
    Science. 1968 Jul 5;161(3836):57-9 PMID: 4298142
  14. Synthesis of cyclic AMP in Dictyostelium discoideum and Polysphondylium pallidum.
    Nature. 1969 Dec 20;224(5225):1211-2 PMID: 4311588
  15. Adenosine-3',5'-phosphate: identification as acrasin in a species of cellular slime mold.
    Science. 1969 Sep 12;165(3898):1133-4 PMID: 4308325
  16. Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture.
    Biochem J. 1970 Sep;119(2):171-4 PMID: 5530748
  17. Extracellular cyclic-amp phosphodiesterase regulation in agar plate cultures of Dictyostelium discoideum.
    Cell Differ. 1976 Apr;5(1):21-5 PMID: 177215
  18. Preliminary characterization of the acrasin of the cellular slime mold Polysphondylium violaceum.
    Proc Natl Acad Sci U S A. 1976 Mar;73(3):795-9 PMID: 3781
  19. Determination of the active portion of the folic acid molecule in cellular slime mold chemotaxis.
    J Bacteriol. 1975 Apr;122(1):185-91 PMID: 164431
  20. Regulation of extracellular cyclic-AMP-phosphodiesterase activity during development of Dictyostelium discoideum.
    Biochem Biophys Res Commun. 1971 Jan 8;42(1):119-24 PMID: 4322968
  21. Studies on the degradation of pterine and pterine-6-carboxylic acid by Pseudomonas fluorescens UK-1.
    Acta Chem Scand B. 1975;29(6):710-4 PMID: 811029
  22. Oscillations and cell development in Dictyostelium discoideum stimulated by folic acid pulses.
    J Cell Sci. 1977;27:105-14 PMID: 201655
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.136.3.955-959.1978
Published
1978-12-00
Pages
955-9
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC218530
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.136.3.955-959.1978 PMC Full Text View journal details
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