A model of alpha-helical distribution in proteins.
It is shown that alpha-helical content of eleven proteins is well correlated with alanine plus leucine content. These residues, taken singly or together, are to a first approximation randomly distributed in the four proteins whose tertiary structures have been determined (i.e., myoglobin, lysozyme, ribonuclease, alpha-chymotrypsin). A model based on the concept that certain randomly distributed residues specifically participate in helix nucleation is shown to be in reasonable agreement with the presently published structures.
23 references, click to expand
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