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PMID: 5697352 Published · ppublish English Journal Article

Ultrastructural study of the liver in hepatic prophyria.

Journal of clinical pathology ·Vol. 21 ·No. 4 ·1968-07-00 ·Pages 501-7

Jean G, Lambertenghi G, Ranzi T

Abstract

In intermittent acute porphyria there are no specific alterations in the ultrastructure of the liver. In contrast, the constant characteristic of porphyria cutanea tarda is siderosis of the hepatocytes and Kupffer cells. Therefore, between the two types of hepatic porphyria there are no similar ultrastructural lesions. It is still doubtful whether the presence of hepatosiderosis in porphyria cutanea tarda is connected with the hepatopathy or is secondary to an alteration in the porphyrinic metabolism. The role played by lysosomes is discussed.

MeSH Terms
Liver/pathology Liver Diseases/pathology Lysosomes Microscopy, Electron Porphyrias/pathology Porphyrins/metabolism Siderosis/pathology
Chemicals
Porphyrins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jean G
Lambertenghi G
Ranzi T
References (28)
28 references, click to expand
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.21.4.501
Published
1968-07-00
Pages
501-7
Language
English
Region
England
NLM ID
0376601
PMCID
PMC473842
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.21.4.501 PMC Full Text View journal details
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