Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in a continuous cell line.

Nature ·Vol. 279 ·No. 5714 ·1979-06-14 ·Pages 604-7

Jokinen M, Gahmberg CG, Andersson LC

Abstract

During biosynthesis of glycophorin A in K562 cells a precursor is rapidly transferred through the endoplasmic reticulum membrane with the COOH-terminal remaining in the cytoplasm. This is glycosylated within the cell and appears at the cell surface after about 30 min. The biosynthetic pathway resembles that described for viral membrane glycoproteins.

MeSH Terms

Amino Acid Sequence Animals Cell Line Glycophorins/biosynthesis Humans Leukemia, Experimental Microsomes/metabolism Molecular Weight Protein Precursors/metabolism Sialoglycoproteins/biosynthesis

Chemicals

Glycophorins Protein Precursors Sialoglycoproteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jokinen M

Gahmberg C G

Andersson L C

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/279604a0

Published

1979-06-14

Pages

604-7

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/279604a0 View journal details

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Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in a continuous cell line.

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