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PMID: 574258 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of chloride on the electrical and mechanical properties of guinea pig ventricle.

Pflugers Archiv : European journal of physiology ·Vol. 381 ·No. 2 ·1979-08-00 ·Pages 171-7

Nosek TM

Abstract

The purpose of this study was to investigate the influence of chloride on the electrical and mechanical properties of the guinea pig ventricular myocardium. Bathing media were made chloride free by substituting the relatively impermeant anion gluconate, isethionate, or sulfate. Removal of chloride increased contractility and decreased the duration of the action potential. Additional experiments explored the influence of chloride free media on electrogenic calcium influx estimated from the magnitude of the action potential in cells partially depolarized by potassium (the slow response). In the absence of chloride, transient increases occurred in the magnitude of the slow response while the positive inotropic effect was maintained. These experiments suggest that the effects of chloride free media are mediated secondarily by an enhanced calcium influx.

MeSH Terms
Animals Calcium/physiology Chlorides/pharmacology Guinea Pigs Heart/physiology Male Membrane Potentials/drug effects Myocardial Contraction/drug effects Ventricular Function
Chemicals
Chlorides Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nosek T M
References (27)
27 references, click to expand
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00582349
Published
1979-08-00
Pages
171-7
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00582349 View journal details
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