Plasminogen-activator-producing tumour.

British medical journal ·Vol. 1 ·No. 5636 ·1969-01-11 ·Pages 88-91

Davidson JF, McNicol GP, Frank GL, Anderson TJ, Douglas AS

Abstract

In a patient with giant-cell carcinoma of the lung a secondary tumour deposit in the arm was incised and bled for three weeks. Investigations showed the tumour to be rich in plasminogen activator. Haemostasis in the tumour was achieved with aminocaproic acid therapy. For a period the plasminogen-activator properties were retained in cell culture of the tumour.

MeSH Terms

Aged Aminocaproates/therapeutic use Arm Carcinoma/metabolism Culture Techniques Female Hemorrhage/drug therapy,etiology Humans Lung Neoplasms/metabolism Neoplasm Metastasis Plasminogen/metabolism

Chemicals

Aminocaproates Plasminogen

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Davidson J F

McNicol G P

Frank G L

Anderson T J

Douglas A S

References (13)

13 references, click to expand

Some properties of the cancer coagulative factor.
Ir J Med Sci. 1961 Mar;423:106-12 PMID: 13730098
Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment.
Blood. 1966 Jul;28(1):1-18 PMID: 5944259
Activation of plasminogen.
Ann N Y Acad Sci. 1957 Aug 30;68(1):38-51 PMID: 13479018
GIANT-CELL CARCINOMA OF THE LUNG: A DEDIFFERENTIATED ADENOCARCINOMA.
Cancer. 1965 Feb;18:259-64 PMID: 14254083
A REVIEW OF UNUSUAL SYSTEMIC MANIFESTATIONS ASSOCIATED WITH CARCINOMA.
Am J Med. 1964 Jan;36:106-20 PMID: 14120080
Origin of fibrinolytic activity in cultures of the human kidney.
J Lab Clin Med. 1967 Oct;70(4):650-61 PMID: 6052965
PLASMA FIBRINOLYTIC ACTIVITY IN RENAL DISEASE.
Scott Med J. 1965 May;10:189-94 PMID: 14298212
LOCALIZATION OF FIBRINOLYTIC ACTIVITY IN TISSUES.
Br Med Bull. 1964 Sep;20:210-2 PMID: 14209761
Prostatic fibrinolysin; study of a case illustrating role in hemorrhagic diathesis of cancer of the prostate.
Am J Med. 1953 Dec;15(6):875-84 PMID: 13104458
Rotation-mediated histogenetic aggregation of dissociated cells. A quantifiable approach to cell interactions in vitro.
Exp Cell Res. 1961 Jan;22:455-75 PMID: 13773012
Giant cell carcinoma of the lung; report of 5 cases.
Cancer. 1958 Mar-Apr;11(2):369-76 PMID: 13511359
A RAPID METHOD FOR VIABLE CELL TITRATION AND CLONE PRODUCTION WITH HELA CELLS IN TISSUE CULTURE: THE USE OF X-IRRADIATED CELLS TO SUPPLY CONDITIONING FACTORS.
Proc Natl Acad Sci U S A. 1955 Jul 15;41(7):432-7 PMID: 16589695
GIANT CELL CARCINOMA OF LUNG.
Cancer. 1963 Aug;16:1080-8 PMID: 14050012

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.5636.88

Published

1969-01-11

Pages

88-91

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1982019

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.5636.88 PMC Full Text

Analysis Services

Plasminogen-activator-producing tumour.

Contact

WeChat Official Account