Fluid phase destruction of C2hu by C1hu. I. Its enhancement and inhibition by homologous and heterologous C4.
The fluid phase inactivation of C2(hu) by C1(hu) is markedly enhanced by the presence of C4(hu). The enhancement is afforded by C1 inactivated C4(hu), namely C4i(hu), and requires the simultaneous presence of enzymatically active C1. Heterologous C4 of guinea pig origin protects C2(hu) from the inactivation by C1(hu). Thus, in both the fluid phase and on the cellular intermediate, C4(hu) is essential to the specific action of C1(hu) on C2(hu). It is possible that C4i alters C2 so as to present a more suitable substrate to the C1 enzyme or that C4i acts on the C1 to uncover a specificity for native C2.
15 references, click to expand
-
Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement.J Exp Med. 1967 Feb 1;125(2):359-80 PMID: 6019133
-
Observations on a pro-esterase associated with partially purified first component of human complement (C'1).Proc Soc Exp Biol Med. 1956 May;92(1):32-7 PMID: 13336065
-
Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.Immunochemistry. 1966 Mar;3(2):111-35 PMID: 5960883
-
Concerning the mechanism of complement action. V. The early steps in immune hemolysis.J Immunol. 1960 Mar;84:299-308 PMID: 13798073
-
Studies on the mechanism of inactivation of human complement by plasmin and by antigen-antibody aggregates. I. The requirement for a factor resembling C'1 and the role of Ca++.J Immunol. 1954 Sep;73(3):146-58 PMID: 13201755
-
Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates.Immunochemistry. 1965 Sep;2(3):219-34 PMID: 4956916
-
C'1 ESTERASE EFFECT ON ACTIVITY AND PHYSICOCHEMICAL PROPERTIES OF THE FOURTH COMPONENT OF COMPLEMENT.J Exp Med. 1965 May 1;121:819-33 PMID: 14280442
-
STUDIES ON HUMAN C'1-ESTERASE. II. FUNCTION OF PURIFIED C'1-ESTERASE IN THE HUMAN COMPLEMENT SYSTEM.J Immunol. 1964 Mar;92:468-78 PMID: 14131465
-
Immune hemolysis: a simplified method for the preparation of EAC'4 with guinea pig or with human complement.J Immunol. 1967 Aug;99(2):263-8 PMID: 4166243
-
Kinetic studies on immune hemolysis. VI. Resolution of the C'y reaction step into two successive processes involving C'2 and C'3.J Immunol. 1954 Dec;73(6):435-42 PMID: 13212067
-
The stoichiometric measurement of the serum inhibition of the first component of complement by the inhibition of immune hemolysis.J Immunol. 1968 Jun;100(6):1154-64 PMID: 4972183
-
EFFECTS OF LOW IONIC STRENGTH ON IMMUNE HEMOLYSIS.J Immunol. 1963 Dec;91:826-32 PMID: 14106307
-
Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency.Immunochemistry. 1966 Jan;3(1):57-69 PMID: 5912034
-
Activation of C'1 to C'1 esterase on gel filtration on Sephadex G-200. Studies on normal human serum, euglobulin and hereditary angioneurotic edema serum.Acta Pathol Microbiol Scand. 1966;68(2):230-42 PMID: 5958663
-
Elution of an esterase from antigen-antibody aggregates treated with human complement.Proc Soc Exp Biol Med. 1956 May;92(1):111-4 PMID: 13336090
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
