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PMID: 5768874 Published · ppublish English Journal Article

Crystalline inclusions in the nuclear envelope and granular endoplasmic reticulum of the fish spinal cord.

The Journal of cell biology ·Vol. 41 ·No. 3 ·1969-06-00 ·Pages 774-85

Marquet E, Sobel HJ

Abstract

Crystalline inclusions were found in the nuclear envelope and granular endoplasmic reticulum of spinal cord oligodendroglia of the common guppy (Poecilia reticulata) and the lungfish (Polypterus enlicheri). A considerably increased incidence of these inclusions was noted in guppies with congenital and hereditary (sex-linked, recessive) lordosis. Identical crystalline inclusions were observed in protoplasmic and fibrous astrocytes, ependymal cells, and capillary endothelial cells of the spinal cord of the lordotic fish. The oligodendroglia in these fish also revealed a prominent alteration of the endoplasmic reticulum and Golgi apparatus, with the accumulation of dense (secretion?) granules and large amounts of electron-opaque material in markedly dilated sacs of the endoplasmic reticulum. The authors postulate that this alteration is caused by a genetic defect in the control mechanism governing the elaboration of this material in the lordotic guppy, with subsequent stasis and crystallization of this material.

MeSH Terms
Animals Cell Nucleus Crystallization Endoplasmic Reticulum Female Fishes Golgi Apparatus Male Microscopy, Electron Neuroglia/cytology Spinal Cord/cytology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Marquet E
Sobel H J
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32 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.41.3.774
Published
1969-06-00
Pages
774-85
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2107819
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.41.3.774 PMC Full Text View journal details
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