Acidaemia and salicylate poisoning in adults.

British medical journal ·Vol. 2 ·No. 5656 ·1969-05-31 ·Pages 547-50

Proudfoot AT, Brown SS

Abstract

A review of the arterial acid-base status on admission to hospital of 62 adults with severe salicylate poisoning showed that arterial pH was normal or high in most patients, but low in 8. The mean plasma salicylate concentrations of the acidaemic and nonacidaemic patients were similar and the difference in arterial pH was associated with a marked fall in standard bicarbonate in the former group. No significant difference of Pco(2) between the two groups was found, and hence no simple relationship exists between hypocapnia and the development of acidaemia in salicylate poisoning. Acidaemia is shown to be associated with impaired consciousness and to carry a grave prognosis.

MeSH Terms

Acidosis/chemically induced Adolescent Adult Aged Bicarbonates/blood Carbon Dioxide/blood Child Female Humans Hydrogen-Ion Concentration Male Middle Aged Prognosis Salicylates/blood,poisoning Unconsciousness

Chemicals

Bicarbonates Salicylates Carbon Dioxide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Proudfoot A T

Brown S S

References (17)

17 references, click to expand

ACID-BASE BALANCE IN CEREBROSPINAL FLUID.
Arch Neurol. 1965 May;12:479-96 PMID: 14288986
Disturbances of acid-base equilibrium in salicylate intoxication.
Pediatrics. 1959 Feb;23(2):260-85 PMID: 13633343
The significance of acid-base measurements in the management of salicylate intoxication.
Postgrad Med J. 1967 Jul;43(501):454-7 PMID: 6041637
ORGANIC ACID EXCRETION IN SALICYLATE INTOXICATION.
J Pediatr. 1965 Mar;66:658-66 PMID: 14264321
The respiratory and circulatory actions of salicylate.
Am J Med. 1955 Oct;19(4):498-508 PMID: 13258583
Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ingestion.
Pediatrics. 1960 Nov;26:800-7 PMID: 13723722
Salicylate intoxication with special reference to the development of hypokalemia.
Am J Med. 1959 Jun;26(6):869-82 PMID: 13649713
TREATMENT OF SEVERE ASPIRIN POISONING WITHOUT DIALYSIS.
Lancet. 1964 Jun 27;2(7348):1409-12 PMID: 14151215
The central respiratory stimulant action of salicylates.
Clin Sci. 1968 Oct;35(2):391-401 PMID: 5721241
CHRONIC SALICYLATE INTOXICATION IN ADULTS.
JAMA. 1965 Aug 16;193:555-8 PMID: 14315187
Salicylate intoxication.
JAMA. 1965 Nov 1;194(5):571 PMID: 5897378
Spinal-fluid pH and neurologic symptoms in systemic acidosis.
N Engl J Med. 1967 Sep 21;277(12):605-13 PMID: 4378309
Specific therapy for salicylism.
N Engl J Med. 1955 Aug 11;253(6):213-7 PMID: 13244803
Overwhelming salicylate intoxication in an adult. Acid-base changes during recovery with hemodialysis.
Arch Intern Med. 1967 Apr;119(4):399-402 PMID: 6022524
The acid-base disturbance in salicylate intoxication.
Medicine (Baltimore). 1954 Feb;33(1):1-13 PMID: 13132255
Effect of hyperbaric-hyperoxic hyperventilation on blood, brain, and CSF lactate.
Am J Physiol. 1968 Nov;215(5):1240-4 PMID: 5687518
Splanchnic lactic acid metabolism in hyperventilation, metabolic alkalosis and shock.
Metabolism. 1967 Jun;16(6):537-47 PMID: 6028805

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5656.547

Published

1969-05-31

Pages

547-50

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1983473

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5656.547 PMC Full Text

Analysis Services

Acidaemia and salicylate poisoning in adults.

Contact

WeChat Official Account