Phenformin-induced hypoglycaemia in normal subjects.

British medical journal ·Vol. 2 ·No. 5651 ·1969-04-26 ·Pages 224-6

Lyngsoe J, Trap-Jensen J

Abstract

Study of the effect of phenformin on the blood glucose level in normal subjects before and during 70 hours of starvation showed a statistically significant hypoglycaemic effect after 40 hours of starvation. This effect was not due to increased glucose utilization.Another finding in this study was a statistically significant decrease in total urinary nitrogen excretion during starvation in subjects given phenformin. These findings show that the hypoglycaemic effect of phenformin in starved normal subjects is due to inhibition of gluconeogenesis.

MeSH Terms

Adult Blood Glucose Gluconeogenesis/drug effects Glucose Tolerance Test Humans Male Nitrogen/urine Phenformin/pharmacology Starvation

Chemicals

Blood Glucose Phenformin Nitrogen

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lyngsoe J

Trap-Jensen J

References (9)

9 references, click to expand

Notes on the glucose oxidase method.
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Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus.
Br Med J. 1962 Jun 2;1(5291):1507-13 PMID: 14467359
Specific inhibition of gluconeogenesis by biguanides.
Nature. 1967 Jan 14;213(5072):203-4 PMID: 6030591
Studies related to the hypoglycemic action of phenethyldiguanide.
Metabolism. 1957 Jul;6(4):311-9 PMID: 13451175
Effect of phenoformin on peripheral glucose utilization in human diabetic and nondiabetic subjects.
Diabetes. 1960 May-Jun;9:202-6 PMID: 14419687
Metabolic effects of phenethylbiguanide in normal subjects and in diabetic patients.
Diabetes. 1960 May-Jun;9:194-201 PMID: 13821364
Inhibition of hepatic gluconeogenesis in guinea pig by phenformin.
Ann N Y Acad Sci. 1968 Mar 26;148(3):612-22 PMID: 4297860
Body glucose kinetics in nondiabetic human subjects after phenethylbiguanide.
Diabetes. 1966 Mar;15(3):173-8 PMID: 5909497
Kinetics of glucose utilization in obesity: the effect of phenformin.
Ann N Y Acad Sci. 1968 Mar 26;148(3):743-55 PMID: 5241473

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5651.224

Published

1969-04-26

Pages

224-6

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1983071

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5651.224 PMC Full Text

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Phenformin-induced hypoglycaemia in normal subjects.

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