Changes in nuclear basic proteins during pseudorabies virus infection.

Journal of virology ·Vol. 3 ·No. 5 ·1969-05-00 ·Pages 490-7

Stevens JG, Kado-Boll GJ, Haven CB

Abstract

As a preliminary study to investigation of the possible role played by basic proteins in the genetic regulation of virus-infected cells, acid-extractable proteins synthesized during pseudorabies virus infection were investigated. The synthesis of histones was found to decrease in a gradual manner, and arrest was complete by 6 hr after infection. Five virus-induced acid-extractable proteins appeared in nuclei of infected cells after 4 hr of infection. Four of these proteins were virus structural proteins; one was not. All these proteins contained tryptophan and, therefore, were not "classic" histones.

MeSH Terms

Animals Arginine/metabolism Carbon Isotopes Cell Line/metabolism Culture Techniques Electrophoresis, Disc Herpesviridae/metabolism Histones/biosynthesis,isolation & purification,metabolism Kidney Lysine/metabolism Protein Hydrolysates/metabolism Pseudorabies Rabbits Tritium Tryptophan/metabolism Viral Proteins/biosynthesis

Chemicals

Carbon Isotopes Histones Protein Hydrolysates Viral Proteins Tritium Tryptophan Arginine Lysine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Stevens J G

Kado-Boll G J

Haven C B

References (14)

14 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.3.5.490-497.1969

Published

1969-05-00

Pages

490-7

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC375799

Subset

External Links

PubMed source DOI: 10.1128/JVI.3.5.490-497.1969 PMC Full Text View journal details

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Changes in nuclear basic proteins during pseudorabies virus infection.

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