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PMID: 5813352 Published · ppublish English Journal Article

Graft versus host inhibition: fetal liver and thymus cells to minimize secondary disease.

Science (New York, N.Y.) ·Vol. 164 ·No. 3877 ·1969-04-18 ·Pages 316-8

Bortin MM, Saltzstein EC

Abstract

Long-lived radiation chimeras were produced in mice diflering at the major histocompatibility locus. Survival occurred in lethally irradiated recipients inoculated with allogeneic fetal liver and allogeneic fetal thymus cells in combination. The survival rate was equal or superior to that of mice with transplanted syngeneic fetal, neonatal, or adult hematopoietic cells.

MeSH Terms
Animals Female Fetus Graft vs Host Disease/immunology Histocompatibility Immunity/radiation effects Liver/cytology,embryology,immunology Mice Pregnancy Radiation Injuries, Experimental/mortality Thymus Gland/cytology,embryology,immunology Transplantation, Homologous
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bortin M M
Saltzstein E C
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1969-04-18
Pages
316-8
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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