Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice.

Journal of bacteriology ·Vol. 98 ·No. 2 ·1969-05-00 ·Pages 494-501

Shands JW, Miller V, Martin H, Senterfitt V

Abstract

The mechanism of the hypoglycemic activity of endotoxin in hyperreactive BCG mice was investigated. The mechanism was found to be an inhibition of the synthesis of glucose from noncarbohydrate sources. The possibilities of an induced hypermetabolic state and an induced release of insulin in response to endotoxin as causes for the hypoglycemic response were essentially ruled out. In addition, no clear-cut evidence of an insulin-like action by endotoxin was found in the in vivo setting.

MeSH Terms

Animals Blood Glucose Butyrates/metabolism Carbon Dioxide/metabolism Carbon Isotopes Cattle Endotoxins Female Gluconeogenesis Hypersensitivity Hypoglycemia/chemically induced Insulin Lactates/blood Mice Oxygen Consumption Pyruvates/blood,metabolism Spirometry Tuberculosis, Bovine/immunology

Chemicals

Blood Glucose Butyrates Carbon Isotopes Endotoxins Insulin Lactates Pyruvates Carbon Dioxide

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Shands J W

Miller V

Martin H

Senterfitt V

References (13)

13 references, click to expand

Localization of endotoxin in the walls of the peripheral vascular system during lethal endotoxemia.
Proc Soc Exp Biol Med. 1962 Nov;111:458-67 PMID: 13982965
HYPOGLYCEMIA FOLLOWING ENDOTOXIN ADMINISTRATION IN ANIMALS WITH LIVER DAMAGE.
Proc Soc Exp Biol Med. 1964 Mar;115:833-7 PMID: 14155841
Studies of the mechanism of the hypoglycemic action of 4-pentenoic acid.
Proc Natl Acad Sci U S A. 1967 Dec;58(6):2299-306 PMID: 5242208
The essential role of the liver in detoxification of endotoxin.
Ann N Y Acad Sci. 1966 Jun 30;133(2):668-84 PMID: 5336354
The blockade of insulin secretion by mannoheptulose.
Isr J Med Sci. 1966 Nov-Dec;2(6):785-99 PMID: 5334156
An o-toluidine method for body-fluid glucose determination.
Clin Chem. 1962 May-Jun;8:215-35 PMID: 13888102
Tissue metabolism in infection. DPNase activity, DPN levels, and DPN-linked dehydrogenases in tissues from normal and tuberculous mice.
Am Rev Respir Dis. 1962 Dec;86:832-8 PMID: 13970359
Inhibition of mitochondrial respiration and uncoupling of oxidative phosphorylation by fractions of the Shigella paradysenteriae type III-somatic antigen.
Arch Biochem Biophys. 1957 Mar;67(1):169-77 PMID: 13412131
Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions.
Immunology. 1961 Oct;4:354-65 PMID: 13918519
Influence of stress on distribution of endotoxin in RES determined by fluorescein antibody technic.
Proc Soc Exp Biol Med. 1957 Jul;95(3):510-3 PMID: 13453488
The impairment of glucogenesis by gram negative infection.
Metabolism. 1968 Jul;17(7):606-11 PMID: 4297876
Effects of bacterial endotoxin on metabolism. I. Carbohydrate depletion and the protective role of cortisone.
J Exp Med. 1959 Sep 1;110:389-405 PMID: 13799887
Metabolism in infection: study on the enzymatic damage in kidney of guinea pig infected with Mycobacterium tuberculosis.
J Exp Med. 1963 Jan 1;117:71-9 PMID: 14020400

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.98.2.494-501.1969

Published

1969-05-00

Pages

494-501

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC284844

Subset

External Links

PubMed source DOI: 10.1128/jb.98.2.494-501.1969 PMC Full Text View journal details

Analysis Services

Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice.

Contact

WeChat Official Account