Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue.

Gut ·Vol. 10 ·No. 8 ·1969-08-00 ·Pages 603-8

Gregory RA, Tracy HJ, Agarwal KL, Grossman MI

Abstract

Two peptides which are potent stimulants of gastric acid secretion are isolated from Zollinger-Ellison tumour tissue. They have aminoacid constitutions identical with those of human gastrin types I and II as isolated from human antral mucosa, and they are present in similar proportions. Their electrophoretic and chromatographic behaviour corresponds to that of human gastrins. Evidence is presented in respect of the one isolated in greater amount that its aminoacid sequence is probably identical with that of human gastrin type I.

MeSH Terms

Amino Acid Sequence Amino Acids/analysis Animals Cats Chromatography, Thin Layer Dogs Electrophoresis Gastric Juice/metabolism Gastrins/analysis Humans Neoplasm Metastasis Pancreas/analysis Peptides/isolation & purification,pharmacology Zollinger-Ellison Syndrome/metabolism

Chemicals

Amino Acids Gastrins Peptides

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Gregory R A

Tracy H J

Agarwal K L

Grossman M I

References (10)

10 references, click to expand

Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin.
Nature. 1965 Sep 25;207(5004):1356-9 PMID: 5886035
Isolation of two gastrins from human antral mucosa.
Nature. 1966 Feb 5;209(5023):583 PMID: 5921182
Nature of the gastric secretagogue in Zollinger-Ellison tumours.
Lancet. 1967 Sep 9;2(7515):543-4 PMID: 4166897
Immunochemical measurement of elevated levels of gastrin in the serum of patients with pancreatic tumors of the Zollinger-Ellison variety.
N Engl J Med. 1968 Jun 13;278(24):1308-13 PMID: 5648596
Production of antibodies to synthetic human gastrin I and radioimmunoassay of gastrin in the serum of patients with the zollinger-ellison syndrome.
Surgery. 1968 Jul;64(1):165-74 PMID: 4173157
Energetics of peptide formation.
Nature. 1952 May 31;169(4309):922 PMID: 14941086
Gastric secretory responses after portal venous ligation.
J Physiol. 1958 Nov 10;144(1):123-37 PMID: 13599113
A method for biologic assay of gastrin.
Gastroenterology. 1961 May;40:644-8 PMID: 13779447
THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA.
Gut. 1964 Apr;5:103-14 PMID: 14159395
THE ANTRAL HORMONE GASTRIN. STRUCTURE OF GASTRIN.
Nature. 1964 Dec 5;204:931-3 PMID: 14248711

Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.10.8.603

Published

1969-08-00

Pages

603-8

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1552899

Subset

External Links

PubMed source DOI: 10.1136/gut.10.8.603 PMC Full Text View journal details

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Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue.

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