Alcohol metabolism: role of microsomal oxidation in vivo.

Science (New York, N.Y.) ·Vol. 166 ·No. 3905 ·1969-10-31 ·Pages 627-8

Tephly TR, Tinelli F, Watkins WD

Abstract

A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.

MeSH Terms

Alcohols/metabolism Animals Carbon Isotopes Ethanol/metabolism Methanol/metabolism Microsomes, Liver/metabolism Oxidation-Reduction Phenobarbital/pharmacology Proadifen/pharmacology Rats

Chemicals

Alcohols Carbon Isotopes Ethanol Proadifen Methanol Phenobarbital

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Tephly T R

Tinelli F

Watkins W D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.166.3905.627

Published

1969-10-31

Pages

627-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.166.3905.627 View journal details

Analysis Services

Alcohol metabolism: role of microsomal oxidation in vivo.

Contact

WeChat Official Account