Synchronization of mammalian cells with tritiated thymidine.

Science (New York, N.Y.) ·Vol. 151 ·No. 3711 ·1966-02-11 ·Pages 691-4

Whitmore GF, Gulyas S

Abstract

Short exposures of mammalian cells to tritiated thymidine of high specific activity destroys the proliferative capacity of mammalian cells. Since the killing is limited to cells that have synthesized DNA in the presence of the labeled compound, an exposure duration of less than one generation can yield a synchronized population.

MeSH Terms

Cell Division/radiation effects Culture Techniques DNA/biosynthesis L Cells Thymidine Tritium

Chemicals

Tritium DNA Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Whitmore G F

Gulyas S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.151.3711.691

Published

1966-02-11

Pages

691-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.151.3711.691 View journal details

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Synchronization of mammalian cells with tritiated thymidine.

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