Studies on the immunochemistry of streptococcal mucopeptide.
Streptococcal mucopeptide, solubilized by either ultrasonic treatment or lysozyme, gave a precipitin reaction with rabbit antimucopeptide serum. A haptenic inhibitor of this reaction, which was composed of alanine, glutamic acid, and lysine in a mole ratio of 4:1:1, was isolated from a Streptomyces albus enzymes digest of Group D cell walls by ion exchange chromatography. When selected antisera were employed, greater than 90% inhibition of the mucopeptide quantitative precipitin reaction was achieved with 2 mg/ml of this inhibitor, whereas a hexosamine fraction with minimal concentrations of amino acid residues was inactive in this respect. These results suggest that the peptide moiety is an antigenic determinant of mucopeptide. Preliminary results indicate that the hexosamine polymer of the mucopeptide is a secondary antigenic determinant.
21 references, click to expand
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Acetylhexosamine compounds enzymically released from Micrococcus lysodeikticus cell walls. I. Isolation and composition of acetylhexosamine and acetylhexosamine-peptide complexes.Biochim Biophys Acta. 1960 Jun 3;40:462-72 PMID: 13827779
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[Data on the structure of disaccharide-peptide complexes liberated from the wall of Micrococcus lysodeikticus by the action of beta(1-4)N-acetylhexosaminidases].Biochim Biophys Acta. 1961 Mar 4;47:561-8 PMID: 13704967
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STRUCTURE OF STREPTOCOCCAL CELL WALLS. 3. CHARACTERIZATION OF AN ALANINE-CONTAINING GLUCOSAMINYLMURAMIC ACID DERIVATIVE LIBERATED BY LYSOZYME FROM STREPTOCOCCAL GLYCOPEPTIDE.J Biol Chem. 1964 Sep;239:2981-5 PMID: 14217885
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Biological properties of streptococcal cell-wall particles. 3. Dermonecrotic reaction to cell-wall mucopeptides.J Bacteriol. 1966 Jan;91(1):374-83 PMID: 4955252
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The partial chemical degradation of the cell walls of Lactobacillus plantarum, Streptococcus faecalis, and Lactobacillus casei.J Biol Chem. 1961 Apr;236:1087-92 PMID: 13717444
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Studies on the chemical structure of the streptococcal cell wall. I. The identification of a mucopeptide in the cell walls of groups A and A-variant streptococci.J Exp Med. 1961 Jul 1;114:127-40 PMID: 13754097
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Chemical structure and biosynthesis of bacterial cell walls.Bacteriol Rev. 1963 Mar;27:18-55 PMID: 13942447
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Amino acids, amino sugars and sugars present in the cell wall of some strains of Streptococcus pyogenes.J Gen Microbiol. 1962 Oct;29:199-205 PMID: 13935500
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IMPROVED TECHNIQUE FOR THE PREPARATION OF STREPTOCOCCAL CELL WALLS.J Bacteriol. 1964 Oct;88:1198-200 PMID: 14219038
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Further studies on the chemical basis for serological specificity of Group A streptococcal carbohydrate.J Exp Med. 1958 Sep 1;108(3):311-23 PMID: 13575668
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The chemical composition of the cell wall in some gram-positive bacteria and its possible value as a taxonomic character.J Gen Microbiol. 1956 Jul;14(3):583-600 PMID: 13346020
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Studies of streptococcal cell walls. III. The amino acids of the trypsin-treated cell wall.J Bacteriol. 1959 Feb;77(2):177-84 PMID: 13630868
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Variation in the group-specific carbohydrate of group A streptococci. II. Studies on the chemical basis for serological specificity of the carbohydrates.J Exp Med. 1956 Nov 1;104(5):629-43 PMID: 13367334
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SYMPOSIUM ON RELATIONSHIP OF STRUCTURE OF MICROORGANISMS TO THEIR IMMUNOLOGICAL PROPERTIES. IV. ANTIGENIC AND BIOCHEMICAL COMPOSITION OF HEMOLYTIC STREPTOCOCCAL CELL WALLS.Bacteriol Rev. 1963 Dec;27:369-80 PMID: 14097346
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Enhanced resistance to streptococcal infection induced in mice by cell wall mucopeptide.J Exp Med. 1965 Nov 1;122(5):877-90 PMID: 5853074
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Chemical structure of teichoic acid from Staphylococcus aureus, strain Copenhagen.J Biol Chem. 1962 Dec;237:3603-13 PMID: 13976222
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Composition of teichoic acids from a number of bacterial walls.Nature. 1959 Jul 25;184:247-8 PMID: 13794315
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IMMUNOLOGICAL PROPERTIES OF BACTERIAL CELL WALL MUCOPEPTIDES.Proc Soc Exp Biol Med. 1965 Feb;118:359-62 PMID: 14268620
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The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus. I. Production and fractionation of the lytic enzymes.J Exp Med. 1952 Dec;96(6):555-68 PMID: 13022850
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Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.Proc Natl Acad Sci U S A. 1965 Oct;54(4):1133-41 PMID: 5219821
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TYPING GROUP A HEMOLYTIC STREPTOCOCCI BY M PRECIPITIN REACTIONS IN CAPILLARY PIPETTES.J Exp Med. 1943 Aug 1;78(2):127-33 PMID: 19871314
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