Biochemical studies of toxic agents. Metabolic ring-fission of cis- and trans-acenaphthene-1,2-diol.

The Biochemical journal ·Vol. 98 ·No. 1 ·1966-01-00 ·Pages 19-24

Hopkins RP, Young L

Abstract

1. The metabolism of cis- and trans-acenaphthene-1,2-diol has been studied after the administration of these compounds to rats by subcutaneous injection and by stomach tube. 2. 1,8-Naphthalic acid has been isolated as its anhydride from the urine of the dosed animals. 3. A spectrophotometric method for the determination of free and conjugated 1,8-naphthalic acid in urine has been developed and has been used in the study of the metabolism of the acenaphthene-1,2-diols. 4. The urine of rats dosed with cis-acenaphthene-1,2-diol by subcutaneous injection was shown by paper chromatography to contain both cis- and trans-acenaphthene-1,2-diol. Similar findings were obtained after the subcutaneous injection of trans-acenaphthene-1,2-diol.

MeSH Terms

Animals Chromatography, Paper Glucuronidase In Vitro Techniques Liver/enzymology Naphthalenes/metabolism Rats Spectrophotometry Urine

Chemicals

Naphthalenes Glucuronidase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hopkins R P

Young L

References (10)

10 references, click to expand

Metabolism of polycyclic compounds. 21. The metabolism of phenanthrene in rabbits and rats: dihydrodihydroxy compounds and related glucosiduronic acids.
Biochem J. 1962 Sep;84:571-82 PMID: 13872198
Metabolism of polycyclic compounds: Production of dihydroxydihydroanthracene from anthracene.
Biochem J. 1935 Dec;29(12):2679-83 PMID: 16745952
Metabolism of polycyclic compounds. 5. Formation of 1:2-dihydroxy-1:2-dihydronaphthalenes.
Biochem J. 1949;44(3):361-5 PMID: 16748527
The properties of maleylacetoacetate, the initial product of homogentisate oxidation in liver.
J Biol Chem. 1955 Oct;216(2):489-98 PMID: 13271329
Biochemical studies of toxic agents. 9. The metabolic conversion of indene into cis- and trans- indane-1: 2-diol.
Biochem J. 1956 Jun;63(2):264-9 PMID: 13328820
MECHANISM OF BETA-KETOADIPATE FORMATION BY BACTERIA.
Nature. 1964 Dec 26;204:1279-83 PMID: 14254410
The metabolic conversion of naphthalene to 1:2-dihydronaphthalene-1:2-diol.
Biochem J. 1947;41(3):417-22 PMID: 16748185
Metabolism of polycyclic compounds. 6. Conversion of phenanthrene into dihydroxydihydrophenanthrenes.
Biochem J. 1950 Jun-Jul;47(1):64-9 PMID: 14791307
Biochemical studies of toxic agents. 13. The metabolism of acenaphthylene.
Biochem J. 1962 Mar;82:457-66 PMID: 14448806
[On the chemistry of benzene glycol. VI. Metabolism of benzene glycols and muconic dialdehydes].
Hoppe Seylers Z Physiol Chem. 1960 May 31;318:171-8 PMID: 13838748

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj0980019

Published

1966-01-00

Pages

19-24

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1264788

Subset

External Links

PubMed source DOI: 10.1042/bj0980019 PMC Full Text View journal details

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Biochemical studies of toxic agents. Metabolic ring-fission of cis- and trans-acenaphthene-1,2-diol.

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