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PMID: 5965097 Published · ppublish English Journal Article

Citrate and the conversion of carbohydrate into fat. Citrate cleavage in obesity and lactation.

The Biochemical journal ·Vol. 99 ·No. 3 ·1966-06-00 ·Pages 760-5

Spencer AF, Lowenstein JM

Abstract

1. The specific activity of ATP citrate lyase is two to four times as great in livers of mice with hereditary obesity as in livers of their non-obese siblings. The enzyme activity in both types of mice can be reduced by starvation, and can be increased by refeeding starved animals. The specific activity of acetyl-CoA synthetase is approximately the same in both types of mice. 2. ATP citrate lyase of mammary gland of the rat undergoes large increases in activity after the onset of lactation. It declines rapidly upon weaning. 3. The changes in activity of ATP citrate lyase in obesity and lactation are consistent with the hypothesis that the enzyme supplies extramitochondrial acetyl-CoA for fatty acid synthesis.

MeSH Terms
Animals Carbohydrate Metabolism Citrates/pharmacology Fatty Acids/biosynthesis Female Lactation Ligases/metabolism Lipids/biosynthesis Liver/enzymology Lyases/metabolism Mice Obesity/genetics,metabolism Pregnancy Pregnancy, Animal Rats Weaning
Chemicals
Citrates Fatty Acids Lipids Lyases Ligases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Spencer A F
Lowenstein J M
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25 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj0990760
Published
1966-06-00
Pages
760-5
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1265067
Subset
IM
External Links
PubMed source DOI: 10.1042/bj0990760 PMC Full Text View journal details
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