Home LiteratureArticle Details
PMID: 5966287 Published · ppublish English Journal Article

Control of haem synthesis by feedback inhibition on human-erythrocyte delta-aminolaevulate dehydratase.

The Biochemical journal ·Vol. 101 ·No. 2 ·1966-11-00 ·Pages 550-2

Calissano P, Bonsignore D, Cartasegna C

Abstract

The action of haem, haemoglobin and other haemoproteins on crude and purified delta-aminolaevulate dehydratase of human erythrocyte is described. The results show a feedback inhibition by haem of porphyrin synthesis at the level of erythrocyte delta-aminolaevulate dehydratase. Some kinetic characteristics of this inhibition are described.

MeSH Terms
Erythrocytes/enzymology Feedback Heme/biosynthesis Humans Hydro-Lyases/metabolism In Vitro Techniques Kinetics Levulinic Acids Porphyrins/biosynthesis
Chemicals
Levulinic Acids Porphyrins Heme Hydro-Lyases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Calissano P
Bonsignore D
Cartasegna C
References (7)
7 references, click to expand
  1. [A simple method of determining delta-amino-levulino-dehydratase in the blood. Behavior of the enzyme in lead poisoning].
    Med Lav. 1965 Mar;56(3):199-205 PMID: 5878891
  2. The purification and properties of ALA dehydratase from human erythrocytes.
    Ital J Biochem. 1966 Jan-Feb;15(1):18-29 PMID: 6015261
  3. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  4. [On the mechanism of erythrocyte ALA dehydratase inhibition by lead].
    Med Lav. 1965 Nov;56(11):727-31 PMID: 5878754
  5. CONTROL OF HEME SYNTHESIS BY FEEDBACK INHIBITION.
    Biochem Biophys Res Commun. 1965 Jan 18;18:243-9 PMID: 14282024
  6. delta-aminolaevulate dehydratase from Rhodopseudomonas spheroides.
    Biochem J. 1963 Jun;87:462-72 PMID: 14041439
  7. THE EFFECT OF HEMIN ON THE SYNTHESIS OF GLOBIN.
    Biochem Biophys Res Commun. 1965 Jan 18;18:236-42 PMID: 14282023
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1010550
Published
1966-11-00
Pages
550-2
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1270139
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1010550 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2