Neoplastic transformation of rat thymic cells induced in vitro by Gross leukemia virus.

Science (New York, N.Y.) ·Vol. 155 ·No. 3762 ·1967-02-03 ·Pages 585-7

Ioachim HL

Abstract

Cultures of embryonal rat thymus infected initially with Gross leukemia virus have, at the present time, abundantly replicated infectious virus particles for 20 months. Cells from these cultures, after 3 months in vitro, displayed morphological changes and induced formation of tumors upon isotransplantation. The tumors were serially transplantable, and subsequent transplants continue to carry the initial Gross leukemia virus.

MeSH Terms

AKR murine leukemia virus Animals Microscopy, Electron Neoplasm Transplantation Rats Thymus Gland/pathology

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ioachim H L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.155.3762.585

Published

1967-02-03

Pages

585-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.155.3762.585 View journal details

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Neoplastic transformation of rat thymic cells induced in vitro by Gross leukemia virus.

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