Immunological release of histamine from bovine leucocytes. Unusual adrenergic modulation.

Immunology ·Vol. 31 ·No. 2 ·1976-08-00 ·Pages 167-70

Holroyde MC, Eyre P

Abstract

Sensitized bovine granulocytes release histamine when exposed to specific antigen. In comparison with in vitro systems in several other species, the modulation of this release by adrenergic agents is unique. Beta-Adrenoceptor stimulation potentiates (rather than inhibits), whereas alpha-adrenoceptor stimulation inhibits (rather than potentiates) histamine release. Adrenaline, which is generally considered to be a physiological antagonist of the anaphylactic reaction, potentiated histamine release in this study. Dopamine, which is present in high concentration in bovine mast cells, was without effect. The results are discussed in terms of the possible role of granulocytes in bovine hypersensitivity.

MeSH Terms

Anaphylaxis Animals Antigen-Antibody Reactions Cattle/immunology Dopamine/pharmacology Epinephrine/pharmacology Granulocytes/immunology Histamine Release/drug effects In Vitro Techniques Isoproterenol/pharmacology Leukocytes/immunology Phentolamine/pharmacology Phenylephrine/pharmacology Propranolol/pharmacology Stimulation, Chemical

Chemicals

Phenylephrine Propranolol Isoproterenol Dopamine Epinephrine Phentolamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Holroyde M C

Eyre P

References (14)

14 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1976-08-00

Pages

167-70

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1445125

Subset

External Links

PubMed source PMC Full Text View journal details

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Immunological release of histamine from bovine leucocytes. Unusual adrenergic modulation.

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