The stereochemistry of the hydrogen elimination in the biological conversion of cholest-7-en-3-beta-ol into cholesterol.
1. The syntheses of Delta(7)-[4-(14)C]cholestenol (XVI, Scheme 3) and Delta(7)-[6alpha-(3)H]-cholestenol (XII, Scheme 2) are described. 2. The metabolism of doubly labelled Delta(7)-cholestenol (II, Scheme 1) by rat-liver homogenates was studied. 3. During the enzymic conversion of Delta(7)-cholestenol into cholesterol (IV, Scheme 1) the 6alpha-hydrogen atom of the former is lost and the overall reaction corresponds to a cis-elimination. 4. In the light of these results various mechanisms for the conversion of Delta(7)-cholestenol into cholesterol are discussed.
5 references, click to expand
-
Pathways of enzymic synthesis and conversion to cholesterol of delta-5,7,24-cholestatrien-3 beta-ol and other naturally occurring sterols.J Biol Chem. 1965 Nov;240(11):4176-88 PMID: 4378934
-
A convenient synthesis of (9,19-3H2)cholecalciferol 3,5-dinitrobenzoate and the mechanism of the precholecalciferol to calciferol reaction.J Chem Soc Perkin 1. 1965 Sep;:5964-8 PMID: 4284866
-
Metabolic transformation of cholestenediols.J Biol Chem. 1965 Dec;240(12):4598-602 PMID: 5846981
-
Agents affecting lipid metabolism. 28. A 7-dehydrocholesterol delta-7-reductase inhibitor (AY-9944) as tool in studies of delta-7-sterol metabolism.Biochemistry. 1966 Mar;5(3):1060-4 PMID: 5911284
-
Conversion of delta7-cholestenol-4-C-14 and 7-dehydro-cholesterol-4-C-14 to cholesterol.J Biol Chem. 1961 Dec;236:3137-40 PMID: 13909337
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
